ReviewInternational journal of hematology2002
Mast cells derived from embryonic stem cells: a model system for studying the effects of genetic manipulations on mast cell development, phenotype, and function in vitro and in vivo.
Review in International journal of hematology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 44 citations in OpenAlex.
- KIT as a master regulator of the mast cell lineage.The Journal of allergy and clinical immunology · 2022Review
- Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.Stem cell reports · 2018Article
- Mast Cells: Key Contributors to Cardiac Fibrosis.International journal of molecular sciences · 2018Review
- Differences in the Importance of Mast Cells, Basophils, IgE, and IgG versus That of CD4Infection and immunity · 2017Article
- Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice.Journal of visualized experiments : JoVE · 2015Article
- Article
- Development of mast cells and importance of their tryptase and chymase serine proteases in inflammation and wound healing.Advances in immunology · 2014Review
- Evidence for the role of mast cells in colon-bladder cross organ sensitization.Autonomic neuroscience : basic & clinical · 2013Article
- Mast cells mediate acute kidney injury through the production of TNF.Journal of the American Society of Nephrology : JASN · 2011Article
- Mast cells in allergic asthma and beyond.Yonsei medical journal · 2010Review
- Autologous blood cell therapies from pluripotent stem cells.Blood reviews · 2010Review
- Mast cell-specific Cre/loxP-mediated recombination in vivo.Transgenic research · 2008Article
- Mast cells: versatile regulators of inflammation, tissue remodeling, host defense and homeostasis.Journal of dermatological science · 2008Review
- Review
- Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo.The American journal of pathology · 2005Article
- Analyzing the roles of mast cells and basophils in host defense and other biological responses.International journal of hematology · 2002Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Large quantities of highly enriched populations of mast cells can be generated from mouse embryonic stem (ES) cells using an in vitro differentiation system. These embryonic stem cell-derived mast cells (ESMCs) exhibit many similarities to mouse bone marrow-derived cultured mast cells (BMCMCs), including the abilities to survive and to orchestrate immunologically specific immunoglobulin E (IgE)-dependent reactions in vivo after transplantation into genetically mast cell-deficient KitW/KitW-v mice. Coupled with the current spectrum of techniques for genetically manipulating ES cells, ESMCs represent a unique model system to analyze the effects of specific alterations in gene structure, expression, or function, including embryonic lethal mutations, on mast cell development, phenotype, and function in vitro and in vivo.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.