ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
bcl-2 Overexpression eliminates deprivation-induced cell death of brainstem auditory neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 65 citations in OpenAlex.
- Deprivation-Induced Plasticity in the Early Central Circuits of the Rodent Visual, Auditory, and Olfactory Systems.eNeuro · 2024Review
- Activity-dependent regulation of the BAX/BCL-2 pathway protects cortical neurons from apoptotic death during early development.Cellular and molecular life sciences : CMLS · 2023Article
- Machine Learning Neuroprotective Strategy Reveals a Unique Set of Parkinson Therapeutic Nicotine Analogs.The open bioinformatics journal · 2020Article
- Neuronal Cell Death.Physiological reviews · 2018Review
- Evaluation of Cerebral White Matter in Prelingually Deaf Children Using Diffusion Tensor Imaging.BioMed research international · 2018Article
- Selective deletion of cochlear hair cells causes rapid age-dependent changes in spiral ganglion and cochlear nucleus neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Murine CMV-induced hearing loss is associated with inner ear inflammation and loss of spiral ganglia neurons.PLoS pathogens · 2015Article
- Thalamus pathology in multiple sclerosis: from biology to clinical application.Cellular and molecular life sciences : CMLS · 2015Review
- Heterogeneous calretinin expression in the avian cochlear nucleus angularis.Journal of the Association for Research in Otolaryngology : JARO · 2014Article
- Transient, afferent input-dependent, postnatal niche for neural progenitor cells in the cochlear nucleus.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Mature neurons: equipped for survival.Cell death & disease · 2013Review
- Afferent regulation of chicken auditory brainstem neurons: rapid changes in phosphorylation of elongation factor 2.The Journal of comparative neurology · 2013Article
- Why do hair cells and spiral ganglion neurons in the cochlea die during aging?Aging and disease · 2011Article
- Bilateral consequences of chronic unilateral deafferentation in the auditory system of the cricket Gryllus bimaculatus.Developmental neuroscience · 2011Article
- Angiogenin prevents serum withdrawal-induced apoptosis of P19 embryonal carcinoma cells.The FEBS journal · 2010Article
- No dramatic age-related loss of hair cells and spiral ganglion neurons in Bcl-2 over-expression mice or Bax null mice.Molecular neurodegeneration · 2010Article
- Age-related loss of spiral ganglion neurons.Hearing research · 2010Review
- Differential gene expression during compensatory sprouting of dendrites in the auditory system of the cricket Gryllus bimaculatus.Insect molecular biology · 2009Article
- Afferent deprivation elicits a transcriptional response associated with neuronal survival after a critical period in the mouse cochlear nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Effects of lithium and deafferentation on expression of glycogen synthase kinase-3beta, NFkappaB, beta-catenin and pCreb in the chick cochlear nucleus.Brain research · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Deprivation of afferent input in young animals results in transneuronal degeneration of postsynaptic sensory neurons in a variety of species and sensory pathways. Transneuronal degeneration is generally not seen in adult animals. The cellular and molecular basis for this dramatic developmental change in susceptibility is not understood. One possibility is that genes involved in the apoptotic process are involved in determining cell death or survival after afferent deprivation. To further investigate this possibility, we performed unilateral cochlear ablation on wild-type and bcl-2-overexpressing mice at a variety of ages. In postnatal day 5 (P5) or P8 wild-type mice, cochlea removal resulted in a 54% or 31% neuronal loss in the anteroventral cochlear nucleus (AVCN), respectively. When the same manipulation is performed on a P30 mouse, no loss of AVCN neurons occurs. This confirmed a rather abrupt change in the sensitivity to disruption of afferent input, a critical period. However, in littermates expressing bcl-2 under a neuron-specific enolase promoter, no significant loss of AVCN neurons was observed at any age after unilateral cochlear ablation. Furthermore, wild-type mice demonstrate rapid expression of activated caspase-3 in AVCN neurons within hours of deafferentation, whereas bcl-2-overexpressing mice do not. This suggests that bcl-2 can influence cell survival after removal of afferent input during the critical period and is consistent with the hypothesis that caspase-3 is one effector of cell death under these circumstances. These data are the first to indicate that known apoptotic mediators can play a role in central neuronal plasticity in models of afferent deprivation.
Indexed as
Identifiers
12040073PMC6758828W2164443122What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.