ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Integrins regulate responsiveness to slit repellent signals.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 75 citations in OpenAlex.
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- Functional Mapping of Adhesiveness on Live Cells Reveals How Guidance Phenotypes Can Emerge From Complex Spatiotemporal Integrin Regulation.Frontiers in bioengineering and biotechnology · 2021Article
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- Integrins Have Cell-Type-Specific Roles in the Development of Motor Neuron Connectivity.Journal of developmental biology · 2019Article
- Tenectin recruits integrin to stabilize bouton architecture and regulate vesicle release at theeLife · 2018Article
- The matrix protein Tiggrin regulates plasmatocyte maturation inDevelopment (Cambridge, England) · 2017Article
- Guiding migration of transplanted glial progenitor cells in the injured spinal cord.Scientific reports · 2016Article
- TGFβ loss activates ADAMTS-1-mediated EGF-dependent invasion in a model of esophageal cell invasion.Experimental cell research · 2015Article
- Building from the Ground up: Basement Membranes in Drosophila Development.Current topics in membranes · 2015Review
- Actin dynamics in growth cone motility and navigation.Journal of neurochemistry · 2014Review
- Connecting the retina to the brain.ASN neuro · 2014Review
- Integrins and cAMP mediate netrin-induced growth cone collapse.Brain research · 2013Article
- A dual role for the βPS integrin myospheroid in mediating Drosophila embryonic macrophage migration.Journal of cell science · 2013Article
- Src inhibits midline axon crossing independent of Frazzled/Deleted in Colorectal Carcinoma (DCC) receptor tyrosine phosphorylation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Laminin/β1 integrin signal triggers axon formation by promoting microtubule assembly and stabilization.Cell research · 2012Article
- 14-3-3ε couples protein kinase A to semaphorin signaling and silences plexin RasGAP-mediated axonal repulsion.Neuron · 2012Article
- Integrins are required for cardioblast polarisation in Drosophila.BMC developmental biology · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Integrins are concentrated within growth cones, but their contribution to axon extension and pathfinding is unclear. Genetic lesion of individual integrins does not stop growth cone extension or motility, but does increase axon defasciculation and axon tract displacement. In this study, we document a dosage-dependent phenotypic interaction between genes for the integrins, their ligands, and the midline growth cone repellent, Slit, but not for the midline attractant, Netrin. Longitudinal tract axons in Drosophila embryos doubly heterozygous for slit and an integrin gene, encoding alphaPS1, alphaPS2, alphaPS3, or betaPS1, take ectopic trajectories across the midline of the CNS. Drosophila doubly heterozygous for slit and the genes encoding the integrin ligands Laminin A and Tiggrin reveal similar errors in midline axon guidance. We propose that the strength of adhesive signaling from integrins influences the threshold of response by growth cones to repellent axon guidance cues.
Indexed as
Identifiers
12040052PMC6758817W1542065996What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.