ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Spatiotemporal features of early neuronogenesis differ in wild-type and albino mouse retina.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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Who cites it
49 citing papers in PubMed.
- Protocol for the purification and culture of primary retinal ganglion cells and development of common pathological models.Journal of molecular histology · 2025Article
- Altered Functional Responses of the Retina in B6 Albino Tyrc/c Mice.Investigative ophthalmology & visual science · 2024Article
- Combination of epigallocatechin 3 gallate and curcumin improves D-galactose and normal-aging associated memory impairment in mice.Scientific reports · 2023Article
- CyclinD2-mediated regulation of neurogenic output from the retinal ciliary margin is perturbed in albinism.Neuron · 2023Article
- Ophthalmological Manifestations of Oculocutaneous and Ocular Albinism: Current Perspectives.Clinical ophthalmology (Auckland, N.Z.) · 2022Review
- Wiring the Binocular Visual Pathways.International journal of molecular sciences · 2019Review
- Conversations with Ray Guillery on albinism: linking Siamese cat visual pathway connectivity to mouse retinal development.The European journal of neuroscience · 2019Review
- Aberrant visual pathway development in albinism: From retina to cortex.Human brain mapping · 2019Article
- Pigmentation and vision: Is GPR143 in control?Journal of neuroscience research · 2019Review
- Molecular guidance cues in the development of visual pathway.Protein & cell · 2018Review
- Retinal Ganglion Cell Diversity and Subtype Specification from Human Pluripotent Stem Cells.Stem cell reports · 2018Article
- The Transcription Factor Prdm16 Marks a Single Retinal Ganglion Cell Subtype in the Mouse Retina.Investigative ophthalmology & visual science · 2017Article
- Progranulin regulates neurogenesis in the developing vertebrate retina.Developmental neurobiology · 2017Article
- Temporal expression of CD184(CXCR4) and CD171(L1CAM) identifies distinct early developmental stages of human retinal ganglion cells in embryonic stem cell derived retina.Experimental eye research · 2017Article
- The Ciliary Margin Zone of the Mammalian Retina Generates Retinal Ganglion Cells.Cell reports · 2016Article
- Retinal pigment epithelial integrity is compromised in the developing albino mouse retina.The Journal of comparative neurology · 2016Article
- Myocyte Dedifferentiation Drives Extraocular Muscle Regeneration in Adult Zebrafish.Investigative ophthalmology & visual science · 2015Article
- Variable phenotypic expressivity in inbred retinal degeneration mouse lines: A comparative study of C3H/HeOu and FVB/N rd1 mice.Molecular vision · 2015Article
- Delayed neurogenesis leads to altered specification of ventrotemporal retinal ganglion cells in albino mice.Neural development · 2014Article
- Connecting the retina to the brain.ASN neuro · 2014Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
In albino mammals, lack of pigment in the retinal pigment epithelium is associated with retinal defects, including poor visual acuity from a photoreceptor deficit in the central retina and poor depth perception from a decrease in ipsilaterally projecting retinal fibers. Possible contributors to these abnormalities are reported delays in neuronogenesis (Ilia and Jeffery, 1996) and retinal maturation (Webster and Rowe, 1991). To further determine possible perturbations in neuronogenesis and/or differentiation, we used cell-specific markers and refined birth dating methods to examine these events during retinal ganglion cell (RGC) genesis in albino and pigmented mice from embryonic day 11 (E11) to E18. Our data indicate that relative to pigmented mice, more ganglion cells are born in the early stages of neuronogenesis in the albino retina, although the initiation of RGC genesis in the albino is unchanged. The cellular organization of the albino retina is perturbed as early as E12. In addition, cell cycle kinetics and output along the nasotemporal axis differ in retinas of albino and pigmented mice, both absolutely, with the temporal aspect of the retina expanded in albino, and relative to the position of the optic nerve head. Finally, blocking melanin synthesis in pigmented eyecups in culture leads to an increase in RGC differentiation, consistent with a role for melanin formation in regulating RGC neuronogenesis. These results point to spatiotemporal defects in neuronal production in the albino retina, which could perturb expression of genes that specify cell fate, number, and/or projection phenotype.
Indexed as
Identifiers
12040030PMC4127325What OpenQuestion holds
Registered trials
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