Are selective COX 2 inhibitors superior to traditional non steroidal anti-inflammatory drugs?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

88 citing papers in PubMed, 7 syntheses or guidelines pooled it, 399 citations in OpenAlex.

1. Pre-emptive and preventive NSAIDs for postoperative pain in adults undergoing all types of surgery.The Cochrane database of systematic reviews · 2021
   Pooled it
2. NSAIDs.BMJ clinical evidence · 2010
   Pooled it
3. NSAIDs.BMJ clinical evidence · 2007
   Pooled it
4. Risk of cardiovascular events and celecoxib: a systematic review and meta-analysis.Journal of the Royal Society of Medicine · 2006
   Pooled it
5. Non-steroidal anti-inflammatory drugs, including cyclo-oxygenase-2 inhibitors, in osteoarthritic knee pain: meta-analysis of randomised placebo controlled trials.BMJ (Clinical research ed.) · 2004
   Pooled it
6. Vardenafil (Levitra) for erectile dysfunction: a systematic review and meta-analysis of clinical trial reports.International journal of impotence research · 2004
   Pooled it
7. Efficacy, tolerability, and upper gastrointestinal safety of celecoxib for treatment of osteoarthritis and rheumatoid arthritis: systematic review of randomised controlled trials.BMJ (Clinical research ed.) · 2002
   Pooled it
8. Efficacy of serratiopeptidase after impacted third molar surgery: a randomized controlled clinical trial.BMC oral health · 2021
   Trial
9. Rofecoxib versus ibuprofen for acute treatment of migraine: a randomised placebo controlled trial.Postgraduate medical journal · 2004
   Trial
10. Lumiracoxib is effective in the treatment of osteoarthritis of the knee: a 13 week, randomised, double blind study versus placebo and celecoxib.Annals of the rheumatic diseases · 2004
    Trial
11. [Treatment of osteoarthritis of the knee joint. Efficacy and tolerance to acemetacin slow release in comparison to celecoxib].Der Orthopade · 2004
    Trial
12. Supporting reanalysis and reuse of clinical trial data: a case study.Trials · 2026
    Article
13. Influence and management of conflicts of interest in randomised clinical trials: qualitative interview study.BMJ (Clinical research ed.) · 2020
    Article
14. Cardiovascular and gastrointestinal safety of selective cyclooxygenase-2 inhibitors: a case/non-case study.International journal of clinical pharmacy · 2018
    Article
15. ClinicalTrials.gov and Drugs@FDA: A Comparison of Results Reporting for New Drug Approval Trials.Annals of internal medicine · 2016
    Article
16. Cardiovascular safety of non-aspirin non-steroidal anti-inflammatory drugs: review and position paper by the working group for Cardiovascular Pharmacotherapy of the European Society of Cardiology.European heart journal. Cardiovascular pharmacotherapy · 2016
    Article
17. Activation of peripheral KCNQ channels attenuates inflammatory pain.Molecular pain · 2014
    Article
18. Comparative analysis and modeling of the severity of steatohepatitis in DDC-treated mouse strains.PloS one · 2014
    Article
19. Why the Cochrane risk of bias tool should include funding source as a standard item.The Cochrane database of systematic reviews · 2013
    Article
20. Cyclooxygenase-1 and -2: molecular targets for cervical neoplasia.Journal of cancer prevention · 2013
    Review

28 more citing papers are in PubMed but not listed here.

Corrections and comments

• Commented on by
  Are selective COX 2 inhibitors superior to traditional NSAIDs? Rofecoxib did not provide unequivocal benefit over traditional NSAIDs.2002
• Commented on by
  Are selective COX 2 inhibitors superior to traditional NSAIDs? Pharmacia's response to editorial.2002
• Commented on by
  Are selective COX 2 inhibitors superior to traditional NSAIDs? Little is known about COX 2 inhibitors.2002
• Commented on by
  Are selective COX 2 inhibitors superior to traditional NSAIDs? Both the CLASS and VIGOR trials support the COX 2 hypothesis.2002
• Commented on by
  [Treatment of osteoarthritis with COX-2 inhibitors: good for the stomach, but bad for the patient?].2002
• Commented on by
  Systematic review of celecoxib for osteoarthritis and rheumatoid arthritis. Celecoxib's relative gastrointestinal safety is overstated.2003
• Commented on by
  Systematic review of celecoxib for osteoarthritis and rheumatoid arthritis. Problems compromise review's validity.2003
• Erratum issued

Authors and funding

3 authors at 2 institutions in 3 countries.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as