ArticleApplied and environmental microbiology2002
Ability of the Listeria monocytogenes strain Scott A to cause systemic infection in mice infected by the intragastric route.
Article in Applied and environmental microbiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 66 citations in OpenAlex.
- Neuroimmune Consequences of L. monocytogenes Infection.Methods in molecular biology (Clifton, N.J.) · 2025Article
- A Cross-Protective Vaccine Against 4b and 1/2bFrontiers in microbiology · 2020Article
- Establishment ofMicroorganisms · 2019Review
- Antilisterial efficacy of Lactobacillus brevis MF179529 from cow: an in vivo evidence.BMC complementary and alternative medicine · 2019Article
- A Comparison of Oral and Intravenous Mouse Models of Listeriosis.Pathogens (Basel, Switzerland) · 2018Review
- Analyzing the innate immunity of NIH hairless mice and the impact of gut microbial polymorphisms onOncotarget · 2017Article
- Gastric Fluid and Heat Stress Response of Listeria monocytogenes Inoculated on Frankfurters Formulated with 10%, 20%, and 30% Fat Content.Korean journal for food science of animal resources · 2014Article
- Animal models for oral transmission of Listeria monocytogenes.Frontiers in cellular and infection microbiology · 2014Review
- Outbreak of Listeria monocytogenes in an urban poultry flock.BMC veterinary research · 2013Article
- Animal models of listeriosis: a comparative review of the current state of the art and lessons learned.Veterinary research · 2012Review
- In vitro properties of a Listeria monocytogenes bacteriophage-resistant mutant predict its efficacy as a live oral vaccine strain.Infection and immunity · 2011Article
- Pregnancy reduces the genetic resistance of C57BL/6 mice to Listeria monocytogenes infection by intragastric inoculation.Microbial pathogenesis · 2011Article
- Article
- Essential role for cyclin D3 in granulocyte colony-stimulating factor-driven expansion of neutrophil granulocytes.Molecular and cellular biology · 2006Article
- Impact of inoculum preparation and storage conditions on the response of Escherichia coli O157:H7 populations to undercooking and simulated exposure to gastric fluid.Applied and environmental microbiology · 2006Article
- Alternative sigma factors and their roles in bacterial virulence.Microbiology and molecular biology reviews : MMBR · 2005Review
- Virulence of Pseudomonas aeruginosa in a murine model of gastrointestinal colonization and dissemination in neutropenia.Infection and immunity · 2005Article
- Oral inoculation of A/J mice for detection of invasiveness differences between Listeria monocytogenes epidemic and environmental strains.Infection and immunity · 2004Article
- Adhesion, invasion, and translocation characteristics of Listeria monocytogenes serotypes in Caco-2 cell and mouse models.Applied and environmental microbiology · 2003Article
- Expression of truncated Internalin A is involved in impaired internalization of some Listeria monocytogenes isolates carried asymptomatically by humans.Infection and immunity · 2003Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Listeriosis is an important food-borne disease that causes high rates of morbidity and mortality. For reasons that are not clear, most large outbreaks of human listeriosis involve Listeria monocytogenes serotype 4b. Relatively little is known about the pathogenesis of listeriosis following gastrointestinal exposure to food-borne disease isolates of L. monocytogenes. In the present study, we investigated the pathogenesis of systemic infection by the food-borne isolate Scott A in an intragastric (i.g.) mouse challenge model. We found that the severity of infection with L. monocytogenes Scott A was increased in mice made neutropenic by administration of monoclonal antibody RB6-8C5. This observation was similar to a previous report on a study with the laboratory strain L. monocytogenes EGD. Prior administration of sodium bicarbonate did not enhance the virulence of L. monocytogenes strain Scott A for i.g. inoculated mice. Following i.g. inoculation of mice, two serotype 4b strains of L. monocytogenes (Scott A and 101M) achieved a greater bacterial burden in the spleen and liver and elicited more severe histopathological damage to those organs than did a serotype 1/2a strain (EGD) and a serotype 1/2b stain (CM). Of the four strains tested, only strain CM exhibited poor survival in synthetic gastric fluid in vitro. The other three strains exhibited similar patterns of survival at pHs of greater than 5 and relatively rapid (<30 min) loss of viability at pHs of less than 5.0. Growth of L. monocytogenes Scott A at temperatures of 12.5 to 37 degrees C did not affect its ability to cause systemic infection in i.g. inoculated mice. These observations suggest that the serotype 4b L. monocytogenes strains Scott A and 101M possess one or more virulence determinants that make them better able to cause systemic infection following inoculation via the g.i. tract than do the serotype 1/2 strains EGD and CM.
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