ArticleApplied and environmental microbiology2002
A gene from Aspergillus nidulans with similarity to URE2 of Saccharomyces cerevisiae encodes a glutathione S-transferase which contributes to heavy metal and xenobiotic resistance.
Article in Applied and environmental microbiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 61 citations in OpenAlex.
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- The Transcription Factor StuA Regulates Oxidative Stress-Responsive Genes inInternational journal of molecular sciences · 2024Article
- Identification of glutathione metabolic genes from a dimorphic fungus Talaromyces marneffei and their gene expression patterns under different environmental conditions.Scientific reports · 2023Article
- Filamentous fungi for sustainable remediation of pharmaceutical compounds, heavy metal and oil hydrocarbons.Frontiers in bioengineering and biotechnology · 2023Review
- The Role of the Glutathione System in Stress Adaptation, Morphogenesis and Virulence of Pathogenic Fungi.International journal of molecular sciences · 2022Review
- Transcriptional Profiling of theInternational journal of molecular sciences · 2022Article
- Increased Accumulation of Squalene in Engineered Yarrowia lipolytica through Deletion ofApplied and environmental microbiology · 2021Article
- Wheat pathogenRSC chemical biology · 2020Article
- The Molecular Mechanism of Perillaldehyde Inducing Cell Death inInternational journal of molecular sciences · 2020Article
- The Mode of Action of Cyclo(l-Ala-l-Pro) in Inhibiting Aflatoxin Production of Aspergillus flavus.Toxins · 2017Article
- Genes conferring copper resistance in Sinorhizobium meliloti CCNWSX0020 also promote the growth of Medicago lupulina in copper-contaminated soil.Applied and environmental microbiology · 2014Article
- Characterization of a Phanerochaete chrysosporium glutathione transferase reveals a novel structural and functional class with ligandin properties.The Journal of biological chemistry · 2012Article
- Characterization of an Nmr homolog that modulates GATA factor-mediated nitrogen metabolite repression in Cryptococcus neoformans.PloS one · 2012Article
- Functional diversification of fungal glutathione transferases from the ure2p class.International journal of evolutionary biology · 2011Article
- Ure2 is involved in nitrogen catabolite repression and salt tolerance via Ca2+ homeostasis and calcineurin activation in the yeast Hansenula polymorpha.The Journal of biological chemistry · 2010Article
- The fungal glutathione S-transferase system. Evidence of new classes in the wood-degrading basidiomycete Phanerochaete chrysosporium.Cellular and molecular life sciences : CMLS · 2009Review
- The glutathione system of Aspergillus nidulans involves a fungus-specific glutathione S-transferase.The Journal of biological chemistry · 2009Article
- Identification of heavy metal-induced genes encoding glutathione S-transferases in the arbuscular mycorrhizal fungus Glomus intraradices.Mycorrhiza · 2006Article
- Comparative genomics of regulation of heavy metal resistance in Eubacteria.BMC microbiology · 2006Article
- Nuclear accumulation of the GATA factor AreA in response to complete nitrogen starvation by regulation of nuclear export.Eukaryotic cell · 2005Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aspergillus nidulans is a saprophytic ascomycete that utilizes a wide variety of nitrogen sources. We identified a sequence from A. nidulans similar to the glutathione S-transferase-like nitrogen regulatory domain of Saccharomyces cerevisiae Ure2. Cloning and sequencing of the gene, designated gstA, revealed it to be more similar to URE2 than the S. cerevisiae glutathione S-transferases. However, creation and analysis of a gstA deletion mutant revealed that the gene does not participate in nitrogen metabolite repression. Instead, it encodes a functional theta class glutathione S-transferase that is involved in resistance to a variety of xenobiotics and metals and confers susceptibility to the systemic fungicide carboxin. Northern analysis showed that gstA transcription is strongly activated upon exposure to 1-chloro-2,4-dinitrobenzene and weakly activated by oxidative stress or growth on galactose as a carbon source. These results suggest that nitrogen metabolite repression in A. nidulans does not involve a homolog of the S. cerevisiae URE2 gene and that the global nitrogen regulatory system differs significantly in these two fungi.
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