ArticleOncogene2002
STAT3 activation is required for interleukin-6 induced transformation in tumor-promotion sensitive mouse skin epithelial cells.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Decursin inhibits tumor progression in head and neck squamous cell carcinoma by downregulating CXCR7 expressionOncology reports · 2022Article
- The Framework for Human Host Immune Responses to Four Types of Parasitic Infections and Relevant Key JAK/STAT Signaling.International journal of molecular sciences · 2021Review
- Dual blockage of STAT3 and ERK1/2 eliminates radioresistant GBM cells.Redox biology · 2019Article
- A Case of Ocular Kaposi's Sarcoma Successfully Treated with Highly Active Antiretroviral Therapy (HAART) Combined with Docetaxel.The American journal of case reports · 2018Article
- Interleukin-6 blockade attenuates lung cancer tissue construction integrated by cancer stem cells.Scientific reports · 2017Article
- MicroRNA-1299 is a negative regulator of STAT3 in colon cancer.Oncology reports · 2017Article
- Article
- Parametrial fat tissue from high fat diet-treated SKH-1 mice stimulates transformation of mouse epidermal JB6 cells.Journal of carcinogenesis & mutagenesis · 2014Article
- Antitumor efficacy of the anti-interleukin-6 (IL-6) antibody siltuximab in mouse xenograft models of lung cancer.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2014Article
- Critical analysis of the potential for targeting STAT3 in human malignancy.OncoTargets and therapy · 2013Article
- Role of STAT3 in cancer metastasis and translational advances.BioMed research international · 2013Review
- HER2-associated radioresistance of breast cancer stem cells isolated from HER2-negative breast cancer cells.Clinical cancer research : an official journal of the American Association for Cancer Research · 2012Article
- Role of NEK6 in tumor promoter-induced transformation in JB6 C141 mouse skin epidermal cells.The Journal of biological chemistry · 2010Article
- Inhibition of STAT3 signaling blocks the anti-apoptotic activity of IL-6 in human liver cancer cells.The Journal of biological chemistry · 2010Article
- Interleukin-6 released from fibroblasts is essential for up-regulation of matrix metalloproteinase-1 expression by U937 macrophages in coculture: cross-talking between fibroblasts and U937 macrophages exposed to high glucose.The Journal of biological chemistry · 2009Article
- Inflammation-associated serum and colon markers as indicators of dietary attenuation of colon carcinogenesis in ob/ob mice.Cancer prevention research (Philadelphia, Pa.) · 2009Article
- A Role for PPARgamma in the Regulation of Cytokines in Immune Cells and Cancer.PPAR research · 2008Article
- Signal transducer and activator of transcription 3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase induction.Neoplasia (New York, N.Y.) · 2007Article
- Expression of interleukin-11 and interleukin-11 receptor alpha in human colorectal adenocarcinoma; immunohistochemical analyses and correlation with clinicopathological factors.World journal of gastroenterology · 2006Article
- PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells.The Journal of cell biology · 2004Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STAT3, a member of signal transducers and activators of transcription (STATs) originally discovered as mediators in cytokine signaling pathways, plays an active role in oncogenesis. However, the function of STAT3 in signaling multistage carcinogenesis, especially in transformation of tumor-promotion sensitive epithelial cells has not been elucidated. The present study demonstrates that STAT3 is activated in interleukin-6 induced transformation in mouse skin epithelial cells. DNA binding and transcriptional activities of STAT3 were significantly increased by interleukin-6. This induced anchorage-independent transformation in tumor-promotion sensitive JB6 mouse skin P+ cells but not in the resistant variant P- cells. Two forms of dominant negative STAT3 (mutant of transcriptional domain, mF, or DNA-binding domain, mD) were stably transfected into P+ cells. Activation of STAT3 was abolished and importantly, interleukin-6 induced anchorage-independent growth was absent in both mutant STAT3 transfectants. To determine the genes targeted by STAT3, three matrix metalloproteinase proteins linked with carcinogenesis of epithelial cells were analysed. Both basal and interleukin-6 induced expression of collagenase I and stromelysin I, but not gelatinase A, were inhibited in the mutant STAT3 transfectants. Furthermore, transfection of a wild type STAT3 restored STAT3 transactivation and response to interleukin-6 induced transformation in mutant STAT3 transfectants, which up-regulated collagenase I and stromelysin I as well. Together, these results provide the first evidence that STAT3 activation is required in the progression of multistage carcinogenesis of mouse skin epithelial cells, and matrix metalloproteinases are actively involved in STAT3-mediated cell transformation.
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