ArticleJournal of clinical microbiology2002
Laboratory diagnosis of human neurocysticercosis: double-blind comparison of enzyme-linked immunosorbent assay and electroimmunotransfer blot assay.
Article in Journal of clinical microbiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Diagnosis and Treatment of Neurocysticercosis: 2017 Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical Medicine and Hygiene (ASTMH).Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Guideline
- Diagnosis and Treatment of Neurocysticercosis: 2017 Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical Medicine and Hygiene (ASTMH).The American journal of tropical medicine and hygiene · 2018Guideline
- Systematic review and meta-analysis estimating association of cysticercosis and neurocysticercosis with epilepsy.PLoS neglected tropical diseases · 2017Pooled it
- Diagnostic Performance of a Multiantigen Print ImmunoAssay (MAPIA) for Antibody Detection in Human Neurocysticercosis.Open forum infectious diseases · 2026Article
- Unveiling neurocysticercosis: A call for heightened awareness and action.Brain & spine · 2025Article
- Mass Spectrometry Identifies Taenia solium Proteins in Sera of Patients With and Without Parenchymal Neurocysticercosis.Parasite immunology · 2024Article
- Pseudotumor - Cysticercosis of the Flexor Digitorum Profundus Mimicking Volkmanns Contracture.Journal of orthopaedic case reports · 2024Article
- Consistent Measurement of Parasite-Specific Antigen Levels in Sera of Patients with Neurocysticercosis Using Two Different Monoclonal Antibody (mAb)-Based Enzyme-Linked Immunosorbent Assays.Pathogens (Basel, Switzerland) · 2023Article
- Update on the diagnosis and management of neurocysticercosis.Arquivos de neuro-psiquiatria · 2022Review
- Imaging correlates of serum enzyme-linked immunoelectrotransfer blot (EITB) positivity in patients with parenchymal neurocysticercosis: results from 521 patients.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2022Article
- Case report and review of literature: Isolated intramedullary spinal neurocysticercosis.Frontiers in neurology · 2022Article
- Subarachnoid Neurocysticercosis Presenting as a New-Onset Seizure in an Immigrant From Guatemala.Cureus · 2021Article
- Collaborative Studies for the Detection ofMicroorganisms · 2021Article
- Diagnostic value of glycoprotein band patterns of three serologic enzyme-linked immunoelectrotransfer blot assays for neurocysticercosis.Parasitology research · 2020Article
- Left-Sided Headache in a Salvadorian Woman.Infectious diseases in clinical practice (Baltimore, Md.) · 2020Article
- Intraventricular adultSurgical neurology international · 2020Article
- Immunodiagnosis of human neurocysticercosis: comparative performance of serum diagnostic tests in Mexico.Parasitology research · 2019Article
- Article
- Low sensitivity and frequent cross-reactions in commercially available antibody detection ELISA assays for Taenia solium cysticercosis.Tropical medicine & international health : TM & IH · 2018Article
- Changes in the seroprevalence of cysticercosis in suspected patients in Chandigarh, India between 1998 and 2014: analysis of 17 years of data.Epidemiology and infection · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurocysticercosis is a common disease in underdeveloped countries. Its diagnosis is based on clinical, imaging (tomography or magnetic resonance), epidemiological, and laboratory data. Several methods based on the detection of antibodies against cysticerci in cerebrospinal fluid or serum have been tested. Among them, an enzyme-linked immunosorbent assay (ELISA) based on the use of a crude parasite antigen has been used by the laboratory network of cysticercosis in Mexico, which has given support to clinicians for up to 7 years. A Taenia solium-specific glycoprotein-based electroimmunotransfer blot (EITB) assay was reported to be highly sensitive and specific for this purpose. In order to compare both techniques, we studied 100 neurocysticercosis patients and 70 neurological noncysticercosis controls and searched for specific antibodies in paired samples of serum and cerebrospinal fluid using both techniques. We found that the EITB assay is more sensitive than the ELISA, especially when serum is being tested. Both techniques are more sensitive in cases with multiple living cysts than in cases with single cysts or calcified lesions. No global differences among cases with parasites located in different parts of the central nervous system were found. In the patients with cysts within the parenchyma, the sensitivity of the EITB assay was higher with serum than with cerebrospinal fluid. The immunodominant bands were found to be the same as those previously reported, i.e., GP-39 to -42, GP-24, and GP-13. Based on these results, we suggest the use of the EITB assay in routine diagnosis of cysticercosis for clinical cases.
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