ArticleJournal of clinical microbiology2002
Multilocus sequence typing of Bordetella pertussis based on surface protein genes.
Article in Journal of clinical microbiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed.
- Genomic epidemiology and multilevel genome typing ofEmerging microbes & infections · 2023Article
- Genome Sequences of Bordetella pertussis Isolates from Outbreaks in Northeastern Mexico.Microbiology resource announcements · 2023Article
- Molecular Evolution and Increasing Macrolide Resistance of Bordetella pertussis, Shanghai, China, 2016-2022.Emerging infectious diseases · 2023Article
- A comprehensive resource for Bordetella genomic epidemiology and biodiversity studies.Nature communications · 2022Article
- Fha DeficientIranian journal of public health · 2021Article
- Genomic Surveillance and Improved Molecular Typing of Bordetella pertussis Using wgMLST.Journal of clinical microbiology · 2021Article
- Rapid and simple SNP genotyping for Bordetella pertussis epidemic strain MT27 based on a multiplexed single-base extension assay.Scientific reports · 2021Article
- Acellular Pertussis Vaccines Induce Anti-pertactin Bactericidal Antibodies Which Drives the Emergence of Pertactin-Negative Strains.Frontiers in microbiology · 2020Article
- Rare Detection of Bordetella pertussis Pertactin-Deficient Strains in Argentina.Emerging infectious diseases · 2019Article
- Molecular epidemiology of Mycoplasma hyorhinis porcine field isolates in the United States.PloS one · 2019Article
- Genomic epidemiology of erythromycin-resistant Bordetella pertussis in China.Emerging microbes & infections · 2019Article
- Hyperbiofilm Formation by Bordetella pertussis Strains Correlates with Enhanced Virulence Traits.Infection and immunity · 2017Article
- Roads to the development of improved pertussis vaccines paved by immunology.Pathogens and disease · 2015Review
- Genome-wide association study identifies SNPs in the MHC class II loci that are associated with self-reported history of whooping cough.Human molecular genetics · 2015Article
- Article
- Whole-genome sequencing reveals the effect of vaccination on the evolution of Bordetella pertussis.Scientific reports · 2015Article
- Analysis of Bordetella pertussis clinical isolates circulating in European countries during the period 1998-2012.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Article
- Studying Bordetella pertussis populations by use of SNPeX, a simple high-throughput single nucleotide polymorphism typing method.Journal of clinical microbiology · 2015Article
- Sequence variation in virulence-related genes of Bordetella pertussis isolates from Poland in the period 1959-2013.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Article
- A Proteomic Characterization of Bordetella pertussis Clinical Isolates Associated with a California State Pertussis Outbreak.International journal of proteomics · 2015Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Despite more than 50 years of vaccination, Bordetella pertussis has remained endemic in The Netherlands, causing epidemic outbreaks every 3 to 5 years. Strain variation may play a role in the persistence of B. pertussis and was studied by sequencing 15 genes coding for surface proteins, including genes for all five components of acellular pertussis vaccines: pertussis toxin (Ptx), pertactin (Prn), filamentous hemagglutinin, and fimbriae (Fim2 and Fim3). A low level of allelic variation was observed, confirming a recent evolutionary origin of B. pertussis. In modern isolates, polymorphism was observed only in prn, ptxS1, ptxS3, and tcfA. Polymorphism in ptxS1, ptxS3, and tcfA was used to categorize isolates in multilocus sequence types (MLSTs). Analysis of Dutch isolates from 1949 to 1999 revealed five MLSTs, which showed a highly dynamic temporal behavior. We observed significant changes in the MLSTs after the introduction of pertussis vaccination in The Netherlands. Epidemic years were found to be associated with the expansion of MLST-4 or MLST-5. MLST-5 showed a remarkable expansion from 10% in 1997 to 80% in 1999. The MLST analysis was extended to a number of widely separated geographic regions: Finland, Italy, Japan, and the United States. MLST-4 and MLST-5 were found to dominate in Italy and the United States. In Finland and Japan, MLST-3 and MLST-2, respectively, were predominant. Thus, although each region showed distinctive MLST frequencies, in three of the five regions MLST-4 and MLST-5 were predominant. These types may represent newly emerged, successful clones. The identification of highly successful clones may shed light on the question of how B. pertussis is able to maintain itself in vaccinated populations.
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