ArticleJournal of clinical microbiology2002
Multilocus sequence typing scheme for Enterococcus faecium.
Article in Journal of clinical microbiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 244 papers.
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Who cites it
244 citing papers in PubMed, 549 citations in OpenAlex.
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- Molecular epidemiology, antimicrobial resistance, and virulence determinants of Enterococcus faecium bloodstream isolates: a 7-year study in Shandong, China.BMC microbiology · 2025Article
- Enteroflow: Automated Pipeline for In Silico Characterization ofInternational journal of molecular sciences · 2025Article
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- Assembly-free typing of Nanopore and Illumina data through proximity scoring with KMA.NAR genomics and bioinformatics · 2025Article
- Genomic Epidemiology of Vancomycin-ResistantAntibiotics (Basel, Switzerland) · 2025Article
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- Genomic insights into the spread of vancomycin- and tigecycline-resistant Enterococcus faecium ST117.Annals of clinical microbiology and antimicrobials · 2025Article
- Characterization of vanA-harboring plasmids supports differentiation of outbreak-related and sporadic vancomycin-resistant Enterococcus faecium isolates in a tertiary care hospital.BMC microbiology · 2025Article
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- Molecular characterization of histidine and tyrosine decarboxylating Enterococcus species isolated from some milk products.BMC microbiology · 2025Article
- Accurate identification ofJournal of medical microbiology · 2025Article
- Isolation ofAntibiotics (Basel, Switzerland) · 2025Article
- High-Risk VREfm Clones and Resistance Determinants in a Thai Hospital.Antibiotics (Basel, Switzerland) · 2025Article
184 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A multilocus sequence typing (MLST) scheme has been developed for Enterococcus faecium. Internal fragments from seven housekeeping genes of 123 epidemiologically unlinked isolates from humans and livestock and 16 human-derived isolates from several outbreaks in the United States, the United Kingdom, Australia, and The Netherlands were analyzed. A total of 62 sequence types were detected in vancomycin-sensitive E. faecium (VSEF) and vancomycin-resistant E. faecium (VREF) isolates. VSEF isolates were genetically more diverse than VREF isolates. Both VSEF and VREF isolates clustered in host-specific lineages that were similar to the host-specific clustering obtained by amplified fragment length polymorphism analysis. Outbreak isolates from hospitalized humans clustered in a subgroup that was defined by the presence of a unique allele from the housekeeping gene purK and the surface protein gene esp. The MLST results suggest that epidemic lineages of E. faecium emerged recently worldwide, while genetic variation in both VREF and VSEF was created by longer-term recombination. The results show that MLST of E. faecium provides an excellent tool for isolate characterization and long-term epidemiologic analysis.
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Registered trials
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