ArticleThe Biochemical journal2002
Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoter.
Article in The Biochemical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 55 citations in OpenAlex.
- Molecular Mechanism Involved in Carotenoid Metabolism in Post-Smolt Atlantic Salmon: Astaxanthin Metabolism During Flesh Pigmentation and Its Antioxidant Properties.Marine biotechnology (New York, N.Y.) · 2021Article
- Molecular Mechanisms for Krüppel-Like Factor 13 Actions in Hippocampal Neurons.Molecular neurobiology · 2020Article
- The Distinct Roles of Transcriptional Factor KLF11 in Normal Cell Growth Regulation and Cancer as a Mediator of TGF-β Signaling Pathway.International journal of molecular sciences · 2020Review
- KLF-1 orchestrates a xenobiotic detoxification program essential for longevity of mitochondrial mutants.Nature communications · 2019Article
- Transcription factor KLF13 inhibits AKT activation and suppresses the growth of prostate carcinoma cells.Cancer biomarkers : section A of Disease markers · 2018Article
- RNA sequencing analysis reveals protective role of kruppel-like factor 3 in colorectal cancer.Oncotarget · 2017Article
- Krüppel-like factors in mammalian stem cells and development.Development (Cambridge, England) · 2017Review
- Novel Roles and Mechanism for Krüppel-like Factor 16 (KLF16) Regulation of Neurite Outgrowth and Ephrin Receptor A5 (EphA5) Expression in Retinal Ganglion Cells.The Journal of biological chemistry · 2016Article
- Establishment of a stable aryl hydrocarbon receptor-responsive HepG2 cell line.Cytotechnology · 2015Article
- KLF/SP Transcription Factor Family Evolution: Expansion, Diversification, and Innovation in Eukaryotes.Genome biology and evolution · 2015Article
- Single and combinatorial chromatin coupling events underlies the function of transcript factor Krüppel-like factor 11 in the regulation of gene networks.BMC molecular biology · 2014Article
- A new family of predicted Krüppel-like factor genes and pseudogenes in placental mammals.PloS one · 2013Article
- Disruption of a novel Kruppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus.The Journal of biological chemistry · 2011Article
- Krüppel-like factor KLF9 regulates PPARγ transactivation at the middle stage of adipogenesis.Cell death and differentiation · 2011Article
- Bimodal, reciprocal regulation of fibroblast growth factor receptor 1 promoter activity by BTEB1/KLF9 during myogenesis.Molecular biology of the cell · 2010Article
- Krüppel-like factors: three fingers in control.Human genomics · 2010Review
- MODY7 gene, KLF11, is a novel p300-dependent regulator of Pdx-1 (MODY4) transcription in pancreatic islet beta cells.The Journal of biological chemistry · 2009Article
- Silencing of the transforming growth factor-beta (TGFbeta) receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signaling.The Journal of biological chemistry · 2009Article
- A network of Krüppel-like Factors (Klfs). Klf8 is repressed by Klf3 and activated by Klf1 in vivo.The Journal of biological chemistry · 2008Article
- Kruppel-like transcription factor 13 regulates T lymphocyte survival in vivo.Journal of immunology (Baltimore, Md. : 1950) · 2007Article
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6 authors at 1 institution in 1 country.
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Abstract
The Sp1-like family of transcription factors is emerging as an integral part of the cellular machinery involved in the control of gene expression. Members of this family of proteins contain three highly homologous C-terminal zinc-finger motifs that bind GC-rich sequences found in the promoters of a diverse number of genes, such as the basic transcription element (BTE) in the promoter of the carcinogen-metabolizing cytochrome P4501A1 (CYP1A1) gene. In the present study, we report the molecular and functional characterization of BTE-binding protein (BTEB) 4, a novel ubiquitously expressed member of the Sp1-like proteins family. This protein represents a new homologue of BTEB1, originally described as a regulator of the BTE site in the CYP1A1 gene promoter. Similarly to the recently described BTEB3, we demonstrate that the N-terminal region of BTEB4 directly represses transcription and binds the co-repressor mSin3A. In addition, we show that the C-terminal zinc-finger domain of BTEB4 binds specifically the BTE site of the CYP1A1 promoter, similar to BTEB1 and BTEB3. Also, we show that both BTEB3 and BTEB4 repress the CYP1A1 gene promoter via the BTE site in HepG2 and BxPC3 cells. Thus the identification of this protein expands the repertoire of BTEB-like members of the Sp1-like protein family involved in transcriptional repression. Furthermore, our results demonstrate that the BTEB subfamily can repress the CYP1A1 gene promoter via the BTE site.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.