ArticleThe Plant cell2002
Physical and functional interaction of the Arabidopsis K(+) channel AKT2 and phosphatase AtPP2CA.
Article in The Plant cell, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
76 citing papers in PubMed, 199 citations in OpenAlex.
- A Salt-ResponsiveInternational journal of molecular sciences · 2026Article
- The multifaceted roles of PP2C phosphatases in plant growth, signaling, and responses to abiotic and biotic stresses.Plant communications · 2025Review
- Structure reveals a regulation mechanism of plant outward-rectifying KProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Potassium extrusion by plant cells: evolution from an emergency valve to a driver of long-distance transport.The New phytologist · 2025Review
- Interactions between Brassinosteroids and Strigolactones in Alleviating Salt Stress in Maize.International journal of molecular sciences · 2024Article
- Research Progress on Plant Shaker KPlants (Basel, Switzerland) · 2024Review
- Transcriptome Profiling Reveals Molecular Responses to Salt Stress in Common Vetch (Plants (Basel, Switzerland) · 2024Article
- Overdominant expression of related genes of ion homeostasis improves KBMC plant biology · 2022Article
- Structural and Functional Insights into the Role of Guard Cell Ion Channels in Abiotic Stress-Induced Stomatal Closure.Plants (Basel, Switzerland) · 2021Review
- A type-2C protein phosphatase (GhDRP1) participates in cotton (Gossypium hirsutum) response to drought stress.Plant molecular biology · 2021Article
- Recent Advances in Genome-wide Analyses of Plant Potassium Transporter Families.Current genomics · 2021Review
- Adjustment of KInternational journal of molecular sciences · 2021Review
- Ubiquitylation of ABA Receptors and Protein Phosphatase 2C Coreceptors to Modulate ABA Signaling and Stress Response.International journal of molecular sciences · 2021Review
- HvAKT2 and HvHAK1 confer drought tolerance in barley through enhanced leaf mesophyll HPlant biotechnology journal · 2020Article
- Response of grafting tobacco to low potassium stress.BMC plant biology · 2020Article
- FRET kinase sensor development reveals SnRK2/OST1 activation by ABA but not by MeJA and high COeLife · 2020Article
- Integration of Abscisic Acid Signaling with Other Signaling Pathways in Plant Stress Responses and Development.Plants (Basel, Switzerland) · 2019Review
- Review
- The Complex Fine-Tuning of K⁺ Fluxes in Plants in Relation to Osmotic and Ionic Abiotic Stresses.International journal of molecular sciences · 2019Review
- Regulation of KFrontiers in plant science · 2019Review
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The AKT2 K(+) channel is endowed with unique functional properties, being the only weak inward rectifier characterized to date in Arabidopsis. The gene is expressed widely, mainly in the phloem but also at lower levels in leaf epiderm, mesophyll, and guard cells. The AKT2 mRNA level is upregulated by abscisic acid. By screening a two-hybrid cDNA library, we isolated a protein phosphatase 2C (AtPP2CA) involved in abscisic acid signaling as a putative partner of AKT2. We further confirmed the interaction by in vitro binding studies. The expression of AtPP2CA (beta-glucuronidase reporter gene) displayed a pattern largely overlapping that of AKT2 and was upregulated by abscisic acid. Coexpression of AtPP2CA with AKT2 in COS cells and Xenopus laevis oocytes was found to induce both an inhibition of the AKT2 current and an increase of the channel inward rectification. Site-directed mutagenesis and pharmacological analysis revealed that this functional interaction involves AtPP2CA phosphatase activity. Regulation of AKT2 activity by AtPP2CA in planta could allow the control of K(+) transport and membrane polarization during stress situations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.