ArticleProceedings of the National Academy of Sciences of the United States of America2002
All-trans-retinal shuts down rod cyclic nucleotide-gated ion channels: a novel role for photoreceptor retinoids in the response to bright light?
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- The Bovine Ex Vivo Retina: A Versatile Model for Retinal Neuroscience.Investigative ophthalmology & visual science · 2023Article
- RNA Biological Characteristics at the Peak of Cell Death in Different Hereditary Retinal Degeneration Mutants.Frontiers in genetics · 2021Article
- Opsin 3 and 4 mediate light-induced pulmonary vasorelaxation that is potentiated by G protein-coupled receptor kinase 2 inhibition.American journal of physiology. Lung cellular and molecular physiology · 2018Article
- Signalling beyond photon absorption: extracellular retinoids and growth factors modulate rod photoreceptor sensitivity.The Journal of physiology · 2016Article
- Cardiac Optogenetics: Enhancement by All-trans-Retinal.Scientific reports · 2015Article
- Easy does it when bleaching isolated mouse rods.The Journal of physiology · 2012Article
- Primary amines protect against retinal degeneration in mouse models of retinopathies.Nature chemical biology · 2011Article
- Vitamin A activates rhodopsin and sensitizes it to ultraviolet light.Visual neuroscience · 2011Article
- Binding of more than one retinoid to visual opsins.Biophysical journal · 2010Article
- Assays for inverse agonists in the visual system.Methods in enzymology · 2010Article
- Retinyl ester homeostasis in the adipose differentiation-related protein-deficient retina.The Journal of biological chemistry · 2008Article
- Interplay between PIP3 and calmodulin regulation of olfactory cyclic nucleotide-gated channels.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Cyclic nucleotide-gated ion channels in rod photoreceptors are protected from retinoid inhibition.The Journal of general physiology · 2006Article
- Dark adaptation of human rod bipolar cells measured from the b-wave of the scotopic electroretinogram.The Journal of physiology · 2006Article
- Visual cycle: Dependence of retinol production and removal on photoproduct decay and cell morphology.The Journal of general physiology · 2006Article
- Access of quaternary ammonium blockers to the internal pore of cyclic nucleotide-gated channels: implications for the location of the gate.The Journal of general physiology · 2006Article
- The pharmacology of cyclic nucleotide-gated channels: emerging from the darkness.Current pharmaceutical design · 2006Review
- Defining the retinoid binding site in the rod cyclic nucleotide-gated channel.The Journal of general physiology · 2005Article
- All-trans-retinal is a closed-state inhibitor of rod cyclic nucleotide-gated ion channels.The Journal of general physiology · 2004Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
In retinal rods, light-induced isomerization of 11-cis-retinal to all-trans-retinal within rhodopsin triggers an enzyme cascade that lowers the concentration of cGMP. Consequently, cyclic nucleotide-gated (CNG) ion channels close, generating the first electrical response to light. After isomerization, all-trans-retinal dissociates from rhodopsin. We now show that all-trans-retinal directly and markedly inhibits cloned rod CNG channels in excised patches. 11-cis-retinal and all-trans-retinol also inhibited the channels, but at somewhat higher concentrations. Single-channel analysis suggests that all-trans-retinal reduces average open probability of rod CNG channels by inactivating channels for seconds at a time. At physiological cGMP levels, all-trans-retinal inhibited in the nanomolar range. Our results suggest that all-trans-retinal may be a potent regulator of the channel in rods during the response to bright light, when there is a large surge in the concentration of all-trans-retinal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.