ArticleNucleic acids research2002
Phenotypic and genotypic variation in methylases involved in type II restriction-modification systems in Helicobacter pylori.
Article in Nucleic acids research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- The complete methylome of Helicobacter pylori UM032.BMC genomics · 2015Article
- Methylome diversification through changes in DNA methyltransferase sequence specificity.PLoS genetics · 2014Article
- Helicobacter pylori DNA methyltransferases and the epigenetic field effect in cancerization.Frontiers in microbiology · 2014Article
- Phylogeographic evidence of cognate recognition site patterns and transformation efficiency differences in H. pylori: theory of strain dominance.BMC microbiology · 2013Article
- Natural transformation of an engineered Helicobacter pylori strain deficient in type II restriction endonucleases.Journal of bacteriology · 2012Article
- Geographic distribution of methyltransferases of Helicobacter pylori: evidence of human host population isolation and migration.BMC microbiology · 2009Article
- The Helicobacter pylori HpyAXII restriction-modification system limits exogenous DNA uptake by targeting GTAC sites but shows asymmetric conservation of the DNA methyltransferase and restriction endonuclease components.Nucleic acids research · 2008Article
- Functional analysis of the M.HpyAIV DNA methyltransferase of Helicobacter pylori.Journal of bacteriology · 2007Article
- Genomic methylation: a tool for typing Helicobacter pylori isolates.Applied and environmental microbiology · 2007Article
- High frequency of gastric colonization with multiple Helicobacter pylori strains in Venezuelan subjects.Journal of clinical microbiology · 2005Article
- Stability of randomly amplified polymorphic DNA fingerprinting in genotyping clinical isolates of Helicobacter pylori.World journal of gastroenterology · 2003Article
- Evolutionary history of hrgA, which replaces the restriction gene hpyIIIR in the hpyIII locus of Helicobacter pylori.Journal of bacteriology · 2003Article
- Helicobacter pylori interstrain restriction-modification diversity prevents genome subversion by chromosomal DNA from competing strains.Nucleic acids research · 2002Article
- Promiscuous methylation of non-canonical DNA sites by HaeIII methyltransferase.Nucleic acids research · 2002Article
- Article
- Role of futC slipped strand mispairing in Helicobacter pylori Lewisy phase variation.Microbes and infectionArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
To determine relationships between Helicobacter pylori geographical origin and type II methylase activity, we examined 122 strains from various locations around the world for methylase expression. Most geographic regions possessed at least one strain resistant to digestion by each of 14 restriction endonucleases studied. Across all of the strains studied, the average number of active methylases was 8.2 +/- 1.9 with no significant variation between the major geographic regions. Although seven pairs of isolates showed the same susceptibility patterns, their cagA/vacA status differed, and the remaining 108 strains each possessed unique patterns of susceptibility. From a single clonal group, 15 of 18 strains showed identical patterns of resistance, but diverged with respect to M.MboII activity. All of the methylases studied were present in all major human population groupings, suggesting that their horizontal acquisition pre-dated the separation of these populations. For the hpyV and hpyAIV restriction-modification systems, an in-depth analysis of genotype, indicating extensive diversity of cassette size and chromosomal locations regardless of the susceptibility phenotype, points toward substantial strain-specific selection involving these loci.
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