Evidence map›Paper›PMID 12034817›Full record

ArticleNucleic acids research2002

Tiny telomere DNA.

Jinsong Ren, Xiaogang Qu, John O Trent, Jonathan B Chaires

Open access · bronzeAbstract read
In one paragraph

Article in Nucleic acids research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 75 citations in OpenAlex.

  1. Thermally Induced Transitions of d(GLife (Basel, Switzerland) · 2022
    Article
  2. Article
  3. Review
  4. Article
  5. Stability of the NaACS omega · 2018
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jinsong RenDepartment of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216-4505, USA.
Xiaogang Qu
John O Trent
Jonathan B Chaires
University of Mississippi Medical Center · US

Funding

SPECIFICITY OF INTERCALATION REACTIONSR01CA035635 · NCI · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI CHAIRES, JONATHAN B. · 1985 to 2014
$2.0M
NCI NIH HHS CA35635NCI NIH HHS R01 CA035635
6 · The paper itself

Abstract

We describe the design, synthesis and biophysical characterization of a novel DNA construct in which a folded quadruplex structure is joined to a standard double helix. Circular dichroism, gel electrophoresis, three-dimensional UV melting and differential scanning calorimetry were all used to characterize the structure. Rigorous molecular dynamics simulations were used to build a plausible atomic-level structural model of the DNA construct. This novel DNA construct provides a model for the duplex-quadruplex junction region at the end of chromosomal DNA and offers a system for the study of structure-selective ligand binding.

Indexed as

Nucleic Acid ConformationBase SequenceCalorimetry, Differential ScanningCircular DichroismDNAG-QuadruplexesLigandsModels, MolecularNucleic Acid DenaturationOligodeoxyribonucleotidesSpectrometry, FluorescenceTelomereThermodynamicsUltraviolet RaysDNALigandsOligodeoxyribonucleotides

Identifiers

PMID12034817
PMCPMC117210
OpenAlexW2132798822

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.