ArticleNucleic acids research2002
Synergistic activation of the rat laminin gamma1 chain promoter by the gut-enriched Kruppel-like factor (GKLF/KLF4) and Sp1.
Article in Nucleic acids research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 50 citations in OpenAlex.
- MMA-induced LOXL2Cell death & disease · 2025Article
- Development potential of extracellular matrix hydrogels as hemostatic materials.Frontiers in bioengineering and biotechnology · 2023Review
- LAMC1 upregulation via TGFβ induces inflammatory cancer-associated fibroblasts in esophageal squamous cell carcinoma via NF-κB-CXCL1-STAT3.Molecular oncology · 2021Article
- TGFβ2 regulates hypothalamic Trh expression through the TGFβ inducible early gene-1 (TIEG1) during fetal development.Molecular and cellular endocrinology · 2015Article
- Laminin α1 regulates age-related mesangial cell proliferation and mesangial matrix accumulation through the TGF-β pathway.The American journal of pathology · 2014Article
- Regulation of mouse lens maturation and gene expression by Krüppel-like factor 4.Experimental eye research · 2013Article
- RNA-binding protein IGF2BP2/IMP2 is required for laminin-β2 mRNA translation and is modulated by glucose concentration.American journal of physiology. Renal physiology · 2012Article
- Krüppel-like transcription factors in the nervous system: novel players in neurite outgrowth and axon regeneration.Molecular and cellular neurosciences · 2011Review
- Regulation of corneal epithelial barrier function by Kruppel-like transcription factor 4.Investigative ophthalmology & visual science · 2011Article
- TGF-beta signal transduction in chronic kidney disease.Frontiers in bioscience (Landmark edition) · 2009Review
- The Krüppel-like factor 9 (KLF9) network in HEC-1-A endometrial carcinoma cells suggests the carcinogenic potential of dys-regulated KLF9 expression.Reproductive biology and endocrinology : RB&E · 2008Article
- Roles of Krüpel-like factor 4 in normal homeostasis, cancer and stem cells.Acta biochimica et biophysica Sinica · 2008Review
- The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiation.The EMBO journal · 2007Article
- Tough beginnings: alterations in the transcriptome of cloned embryos during the first two cell cycles.Developmental biology · 2007Article
- Tip60 functions as a potential corepressor of KLF4 in regulation of HDC promoter activity.Nucleic acids research · 2007Article
- KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation.The Journal of experimental medicine · 2004Article
- Kruppel-like factors regulate the Lama1 gene encoding the laminin alpha1 chain.The Journal of biological chemistry · 2004Article
- Convergence of the thyroid hormone and gut-enriched Krüppel-like factor pathways in the context of enterocyte differentiation.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2003Article
- Down-regulation of gut-enriched Kruppel-like factor expression in esophageal cancer.World journal of gastroenterology · 2002Article
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
Laminin is a multifunctional heterotrimeric protein present in extracellular matrix where it regulates processes that compose tissue architecture including cell differentiation. Laminin gamma1 is the most widely expressed laminin chain and its absence causes early lethality in mouse embryos. Laminin gamma1 chain gene (LAMC1) promoter contains several GC/GT-rich motifs including the bcn-1 element. Using the bcn-1 element as a bait in the yeast one-hybrid screen, we cloned the gut-enriched Kruppel-like factor (GKLF or KLF4) from a rat mesangial cell library. We show that GKLF binds bcn-1, but this binding is not required for the GKLF-mediated activation of the LAMC1 promoter. The activity of GKLF is dependent on a synergism with another Kruppel-like factor, Sp1. The LAMC1 promoter appears to have multiple GKLF- and Sp1-responsive elements which may account for the synergistic activation. We provide evidence that the synergistic action of GKLF and Sp1 is dependent on the promoter context and the integrity of GKLF activation and DNA-binding domain. GKLF is thought to participate in the switch from cell proliferation to differentiation. Thus, the Sp1-GKLF synergistic activation of the LAMC1 promoter may be one of the avenues for expression of laminin gamma1 chain when laminin is needed to regulate cell differentiation.
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