ArticleEMBO reports2002
Initial activation of cyclin-B1-cdc2 kinase requires phosphorylation of cyclin B1.
Article in EMBO reports, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 48 citations in OpenAlex.
- The Proapoptotic Effect of MB-653 Is Associated with the Modulation of Metastasis and Invasiveness-Related Signalling Pathways in Human Colorectal Cancer Cells.Biomolecules · 2025Article
- Molecular mechanism of human ISG20L2 for the ITS1 cleavage in the processing of 18S precursor ribosomal RNA.Nucleic acids research · 2024Article
- Cell Cycle-Related Gene SPC24: A Novel Potential Diagnostic and Prognostic Biomarker for Laryngeal Squamous Cell Cancer.BioMed research international · 2023Article
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- Overexpression of protein regulator of cytokinesis 1 facilitates tumor growth and indicates unfavorable prognosis of patients with colon cancer.Cancer cell international · 2020Article
- Cyclin B2 can compensate for Cyclin B1 in oocyte meiosis I.The Journal of cell biology · 2018Article
- A High-Resolution Proteomic Landscaping of Primary Human Dental Stem Cells: Identification of SHED- and PDLSC-Specific Biomarkers.International journal of molecular sciences · 2018Article
- miR‑342‑5p promotes Zmpste24‑deficient mouse embryonic fibroblasts proliferation by suppressing GAS2.Molecular medicine reports · 2017Article
- Prognostic significance of G2/M arrest signaling pathway proteins in advanced non-small cell lung cancer patients.Oncology letters · 2015Article
- Release from meiotic arrest in ascidian eggs requires the activity of two phosphatases but not CaMKII.Development (Cambridge, England) · 2013Article
- Distinct pools of cdc25C are phosphorylated on specific TP sites and differentially localized in human mitotic cells.PloS one · 2010Article
- Review
- Combination of a new generation of PNAs with a peptide-based carrier enables efficient targeting of cell cycle progression.Gene therapy · 2004Article
- Localization and dynamics of Cdc2-cyclin B during meiotic reinitiation in starfish oocytes.Molecular biology of the cell · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
At the G(2)/M transition of the cell cycle, the cdc25c phosphatase dephosphorylates inhibitory residues of cdc2, and cyclin-B-cdc2 kinase (MPF) is activated. Phosphorylation of cyclin B1 induces its nuclear accumulation, and, since cdc25c is also believed to accumulate and activate shortly before G(2)/M in the nucleus, it has been proposed that this induces cyclin-B1-cdc2 kinase activation. We demonstrate that cyclin B1 phosphorylation has another essential function in vivo: it is required for cdc25c and MPF activation, which does not require nuclear accumulation of cyclin B1, and occurs in the cytoplasm.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.