ArticleEMBO reports2002
STAG2 and Rad21 mammalian mitotic cohesins are implicated in meiosis.
Article in EMBO reports, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 82 citations in OpenAlex.
- Chromosome Architecture Defined by the Meiosis-Specific Cohesin in Mammalian Germ Cells.Advances in experimental medicine and biology · 2026Review
- Analysis of absolute amounts of two meiotic cohesin subunits, RAD21L and REC8, in mouse spermatocytes.The Journal of reproduction and development · 2023Article
- Article
- Is age-related increase of chromosome segregation errors in mammalian oocytes caused by cohesin deterioration?Reproductive medicine and biology · 2020Review
- The cohesin complex in mammalian meiosis.Genes to cells : devoted to molecular & cellular mechanisms · 2019Review
- Meiotic cohesin subunits RAD21L and REC8 are positioned at distinct regions between lateral elements and transverse filaments in the synaptonemal complex of mouse spermatocytes.The Journal of reproduction and development · 2016Article
- Proteomics Analysis with a Nano Random Forest Approach Reveals Novel Functional Interactions Regulated by SMC Complexes on Mitotic Chromosomes.Molecular & cellular proteomics : MCP · 2016Article
- CTCF contributes in a critical way to spermatogenesis and male fertility.Scientific reports · 2016Article
- High density of REC8 constrains sister chromatid axes and prevents illegitimate synaptonemal complex formation.EMBO reports · 2016Article
- Genetic Interactions Between the Meiosis-Specific Cohesin Components, STAG3, REC8, and RAD21L.G3 (Bethesda, Md.) · 2016Article
- The Proteomic Profile of Deleted in Breast Cancer 1 (DBC1) Interactions Points to a Multifaceted Regulation of Gene Expression.Molecular & cellular proteomics : MCP · 2016Article
- Article
- Development of a protein marker panel for characterization of human induced pluripotent stem cells (hiPSCs) using global quantitative proteome analysis.Stem cell research · 2015Article
- Divergent kleisin subunits of cohesin specify mechanisms to tether and release meiotic chromosomes.eLife · 2014Article
- The cohesin subunit Rad21 is required for synaptonemal complex maintenance, but not sister chromatid cohesion, during Drosophila female meiosis.PLoS genetics · 2014Article
- STAG3-mediated stabilization of REC8 cohesin complexes promotes chromosome synapsis during meiosis.The EMBO journal · 2014Article
- Meiotic cohesin STAG3 is required for chromosome axis formation and sister chromatid cohesion.The EMBO journal · 2014Article
- Cohesin removal precedes topoisomerase IIα-dependent decatenation at centromeres in male mammalian meiosis II.Chromosoma · 2014Article
- The roles of cohesins in mitosis, meiosis, and human health and disease.Methods in molecular biology (Clifton, N.J.) · 2014Review
- Dynamics of cohesin subunits in grasshopper meiotic divisions.Chromosoma · 2013Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STAG/SA proteins are specific cohesin complex subunits that maintain sister chromatid cohesion in mitosis and meiosis. Two members of this family, STAG1/SA1 and STAG2/SA2,double dagger are classified as mitotic cohesins, as they are found in human somatic cells and in Xenopus laevis as components of the cohesin(SA1) and cohesin(SA2) complexes, in which the shared subunits are Rad21/SCC1, SMC1 and SMC3 proteins. A recently reported third family member, STAG3, is germinal cell-specific and is a subunit of the meiotic cohesin complex. To date, the meiosis-specific cohesin complex has been considered to be responsible for sister chromatid cohesion during meiosis. We studied replacement of the mitotic by the meiotic cohesin complex during mouse germinal cell maturation, and we show that mammalian STAG2 and Rad21 are also involved in several meiosis stages. Immunofluorescence results suggest that a cohesin complex containing Rad21 and STAG2 cooperates with a STAG3-specific complex to maintain sister chromatid cohesion during the diplotene stage of meiosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.