ArticleThe Biochemical journal2002
Macrophage uptake of low-density lipoprotein bound to aggregated C-reactive protein: possible mechanism of foam-cell formation in atherosclerotic lesions.
Article in The Biochemical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 99 citations in OpenAlex.
- Evaluating the effect of the antiPCSK9 vaccine on systemic inflammation and oxidative stress in an experimental mouse model.Cardiology journal · 2025Article
- Article
- C-Reactive Protein in Atherosclerosis-More than a Biomarker, but not Just a Culprit.Reviews in cardiovascular medicine · 2023Review
- Anti-Inflammatory Therapy in Coronary Artery Disease: Where Do We Stand?Reviews in cardiovascular medicine · 2023Review
- Regulation of Conformational Changes in C-reactive Protein Alters its Bioactivity.Cell biochemistry and biophysics · 2022Review
- mCRP as a Biomarker of Adult-Onset Still's Disease: Quantification of mCRP by ELISA.Frontiers in immunology · 2022Article
- Functionality of C-Reactive Protein for Atheroprotection.Frontiers in immunology · 2019Review
- LOX-1 is a poor prognostic indicator and induces epithelial-mesenchymal transition and metastasis in pancreatic cancer patients.Cellular oncology (Dordrecht, Netherlands) · 2018Article
- pCRP-mCRP Dissociation Mechanisms as Potential Targets for the Development of Small-Molecule Anti-Inflammatory Chemotherapeutics.Frontiers in immunology · 2018Review
- Functional Transformation of C-reactive Protein by Hydrogen Peroxide.The Journal of biological chemistry · 2017Article
- Recognition functions of pentameric C-reactive protein in cardiovascular disease.Mediators of inflammation · 2014Review
- The effect of two iso-caloric meals containing equal amounts of fats with a different fat composition on the inflammatory and metabolic markers in apparently healthy volunteers.Journal of inflammation (London, England) · 2013Article
- Estradiol inhibits vascular endothelial cells pro-inflammatory activation induced by C-reactive protein.Molecular and cellular biochemistry · 2013Article
- Atherosclerosis-related functions of C-reactive protein.Cardiovascular & hematological disorders drug targets · 2010Article
- Study of the interaction of the C-reactive protein monomer with the U937 monocyte.Cellular & molecular biology letters · 2010Article
- C-reactive protein induced rearrangement of phosphatidylcholine on nanoparticle mimics of lipoprotein particles.The journal of physical chemistry. B · 2010Article
- Functional analysis of the C-reactive protein (CRP) gene -717A>G polymorphism associated with coronary heart disease.BMC medical genetics · 2009Article
- Phosphoethanolamine-complexed C-reactive protein: a pharmacological-like macromolecule that binds to native low-density lipoprotein in human serum.Clinica chimica acta; international journal of clinical chemistry · 2008Article
- Human C-reactive protein promotes oxidized low density lipoprotein uptake and matrix metalloproteinase-9 release in Wistar rats.Journal of lipid research · 2008Article
- C-reactive protein-bound enzymatically modified low-density lipoprotein does not transform macrophages into foam cells.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Foam cells found in atherosclerotic lesions are believed to derive from macrophages that take up aggregated low-density lipoprotein (LDL) particles bound to the extracellular matrix of arterial walls. C-reactive protein (CRP) is an acute-phase protein found in atherosclerotic lesions, which when immobilized on a solid phase, can bind and cluster LDL particles in a calcium-dependent manner. In the present study, we examined whether CRP-bound aggregated LDL could be taken up by macrophages in culture. CRP molecules were aggregated in the presence of calcium and immobilized on the surface of polystyrene microtitre wells. Human LDL added to the wells bound to and aggregated on the immobilized CRP, also in a calcium-dependent manner. On incubation with macrophages, the immobilized CRP-bound LDL aggregates were readily taken up by the cells, as demonstrated by immunofluorescence microscopy, by the cellular accumulation of cholesterol and by the overexpression of adipophilin. Immunofluorescence microscopy and flow-cytometry analysis established that the uptake of the LDL-CRP complex was not mediated by the CRP receptor CD32. These observations with immobilized CRP and LDL, approximating the conditions that exist in the extracellular matrix of the arterial wall, thus suggest that CRP may contribute to the formation of foam cells in atherosclerotic lesions by causing the aggregation of LDL molecules that are then taken up by macrophages through a CD32-independent pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.