ArticleOncogene2002
Global genome repair of 8-oxoG in hamster cells requires a functional CSB gene product.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 51 citations in OpenAlex.
- Mechanistic and biological considerations of oxidatively damaged DNA for helicase-dependent pathways of nucleic acid metabolism.Free radical biology & medicine · 2017Review
- Repair of hydantoin lesions and their amine adducts in DNA by base and nucleotide excision repair.Journal of the American Chemical Society · 2013Article
- Downregulation of Cockayne syndrome B protein reduces human 8-oxoguanine DNA glycosylase-1 expression and repair of UV radiation-induced 8-oxo-7,8-dihydro-2'-deoxyguanine.Cancer science · 2011Article
- Early host cell reactivation of an oxidatively damaged adenovirus-encoded reporter gene requires the Cockayne syndrome proteins CSA and CSB.Mutagenesis · 2011Article
- Preferential repair of the transcribed DNA strand in plants.Frontiers in plant science · 2011Article
- Host DNA repair proteins in response to Pseudomonas aeruginosa in lung epithelial cells and in mice.Infection and immunity · 2011Article
- Synergistic chemosensitivity of triple-negative breast cancer cell lines to poly(ADP-Ribose) polymerase inhibition, gemcitabine, and cisplatin.Cancer research · 2010Article
- Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Mitochondrial DNA, base excision repair and neurodegeneration.DNA repair · 2008Review
- The involvement of DNA-damage and -repair defects in neurological dysfunction.American journal of human genetics · 2008Review
- Base-excision repair of oxidative DNA damage.Nature · 2007Review
- Cockayne syndrome B protein stimulates apurinic endonuclease 1 activity and protects against agents that introduce base excision repair intermediates.Nucleic acids research · 2007Article
- Cooperation of the Cockayne syndrome group B protein and poly(ADP-ribose) polymerase 1 in the response to oxidative stress.Molecular and cellular biology · 2005Article
- Different effects of CSA and CSB deficiency on sensitivity to oxidative DNA damage.Molecular and cellular biology · 2004Article
- Cockayne syndrome group B cellular and biochemical functions.American journal of human genetics · 2003Review
- Poly(ADP-ribosyl)ation accelerates DNA repair in a pathway dependent on Cockayne syndrome B protein.Nucleic acids research · 2003Article
- Article
- The role of XPC: implications in cancer and oxidative DNA damage.Mutation researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cockayne syndrome (CS) is an autosomal recessive human disease characterized by UV-sensitivity as well as neurological and developmental abnormalities. Two complementation groups have been established, designated CS-A and CS-B. Traditionally, CSA and CSB have been ascribed a function in the transcription-coupled repair (TCR) pathway of nucleotide excision repair (NER) that efficiently removes bulky lesions from the transcribed strand of RNA polymerase II transcribed genes. To assess the role of the CSB protein in the repair of the highly mutagenic base lesion 7,8-dihydro-8-oxoguanine (8-oxoG), we have investigated the removal of this lesion using an in vitro incision approach with cell extracts as well as an in vivo approach with a modified protocol of the gene-specific repair assay, which allows the measurement of base lesion repair in intragenomic sequences. Our results demonstrate that the integrity of the CSB protein is pivotal for processes leading to incision at the site of 8-oxoG and that the global genome repair (GGR) of this lesion requires a functional CSB gene product in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.