ArticleOncogene2002
N-myc oncogene overexpression down-regulates IL-6; evidence that IL-6 inhibits angiogenesis and suppresses neuroblastoma tumor growth.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 66 citations in OpenAlex.
- The Diverse Function of IL-6 in Biological Processes and the Advancement of Cancer.Immune network · 2025Review
- Article
- Neuroprotective Effects of Estradiol plus Lithium Chloride via Anti-Apoptosis and Neurogenesis Pathway inParkinson's disease · 2021Article
- VEGFR2 survival and mitotic signaling depends on joint activation of associated C3ar1/C5ar1 and IL-6R-gp130.Journal of cell science · 2019Article
- Proline-rich tyrosine kinase 2 via enhancing signal transducer and activator of transcription 3-dependent cJun expression mediates retinal neovascularization.Scientific reports · 2016Article
- Serum-circulating miRNAs predict neuroblastoma progression in mouse model of high-risk metastatic disease.Oncotarget · 2016Article
- Tumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategies.Cancer metastasis reviews · 2015Review
- Inhibition of NF-κB in Tumor Cells Exacerbates Immune Cell Activation Following Photodynamic Therapy.International journal of molecular sciences · 2015Article
- Radiation-induced angiogenic signaling pathway in endothelial cells obtained from normal and cancer tissue of human breast.Oncogene · 2014Article
- Neuroblastoma and MYCN.Cold Spring Harbor perspectives in medicine · 2013Review
- MYCN-mediated transcriptional repression in neuroblastoma: the other side of the coin.Frontiers in oncology · 2013Article
- Targeting angiogenesis in childhood sarcomas.Sarcoma · 2011Article
- Neuroblastoma progression correlates with downregulation of the lymphangiogenesis inhibitor sVEGFR-2.Clinical cancer research : an official journal of the American Association for Cancer Research · 2010Article
- Chemoresistance acquisition induces a global shift of expression of aniogenesis-associated genes and increased pro-angogenic activity in neuroblastoma cells.Molecular cancer · 2009Article
- Transcription factors: their potential as targets for an individualized therapeutic approach to cancer.Cancer gene therapy · 2009Review
- Interleukin-6 in the bone marrow microenvironment promotes the growth and survival of neuroblastoma cells.Cancer research · 2009Article
- Interleukin-6 and soluble interleukin-6 receptor levels as markers of disease extent and prognosis in neuroblastoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2008Article
- Interleukin-6, secreted by human ovarian carcinoma cells, is a potent proangiogenic cytokine.Cancer research · 2005Article
- Absence of PAF actions increases angiogenesis.British journal of pharmacology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Angiogenesis is an indispensable prerequisite for the progression and metastasis of solid malignancies. Tumor angiogenesis appears to be governed by alterations of tumor suppressor or oncogenes operant in a broad range of tumors. We have addressed this issue in neuroblastoma, a malignancy characterized by the near-exclusive amplification and overexpression of the N-Myc oncogene. Here, we report that N-Myc overexpression results in down-regulation of interleukin-6 (IL-6) and that IL-6 is an inhibitor of endothelial cell proliferation and VEGF-induced rabbit corneal angiogenesis. STAT3 is instrumental for IL-6 activity as infection with adenoviruses expressing a phosphorylation deficient STAT3 mutant renders endothelial cells insensitive to the antiproliferative action of IL-6. Finally, though IL-6 does not influence neuroblastoma cell growth, IL-6-expressing xenograft tumors in mice exhibit reduced neovascularization and suppressed growth. Our data shed new light on the mechanisms by which N-myc oncogene amplification enhances the malignant phenotype in neuroblastomas.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.