ArticleOncogene2002
Human telomerase accelerates growth of lens epithelial cells through regulation of the genes mediating RB/E2F pathway.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 86 citations in OpenAlex.
- The aging eye: navigating molecular mechanisms and innovative interventions.Biogerontology · 2026Review
- TERT Extra-Telomeric Roles: Antioxidant Activity and Mitochondrial Protection.International journal of molecular sciences · 2023Article
- Article
- Many Functions of Telomerase Components: Certainties, Doubts, and Inconsistencies.International journal of molecular sciences · 2022Review
- Non-canonical roles of canonical telomere binding proteins in cancers.Cellular and molecular life sciences : CMLS · 2021Review
- CCNDBP1, a Prognostic Marker Regulated by DNA Methylation, Inhibits Aggressive Behavior in Dedifferentiated LiposarcomaFrontiers in oncology · 2021Article
- Melatonin synergizes BRAF-targeting agent dabrafenib for the treatment of anaplastic thyroid cancer by inhibiting AKT/hTERT signalling.Journal of cellular and molecular medicine · 2020Article
- Endothelial senescence is induced by phosphorylation and nuclear export of telomeric repeat binding factor 2-interacting protein.JCI insight · 2019Article
- Telomerase reverse transcriptase induced thyroid carcinoma cell proliferation through PTEN/AKT signaling pathway.Molecular medicine reports · 2018Article
- Article
- hTERT promotes cell adhesion and migration independent of telomerase activity.Scientific reports · 2016Article
- Saccharomyces cerevisiae as a model for the study of extranuclear functions of mammalian telomerase.Current genetics · 2015Article
- MST-312 induces G2/M cell cycle arrest and apoptosis in APL cells through inhibition of telomerase activity and suppression of NF-κB pathway.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- GCIP functions as a tumor suppressor in non-small cell lung cancer by suppressing Id1-mediated tumor promotion.Oncotarget · 2014Article
- An investigation of the effects of the core protein telomerase reverse transcriptase on Wnt signaling in breast cancer cells.Molecular and cellular biology · 2014Article
- Alternatively spliced telomerase reverse transcriptase variants lacking telomerase activity stimulate cell proliferation.Molecular and cellular biology · 2012Article
- Telomere lengthening and other functions of telomerase.Acta naturae · 2012Article
- Knockdown of Akt1 promotes Akt2 upregulation and resistance to oxidative-stress-induced apoptosis through control of multiple signaling pathways.Antioxidants & redox signaling · 2011Article
- Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis.PloS one · 2008Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Telomerase is a specialized reverse transcriptase that extends telomeres of eukaryotic chromosomes. The catalytic core of human telomerase is composed of an RNA template known as hTER (human telomerase RNA) and a protein subunit named hTERT (human telomerase reverse transcriptase). We have been studying other functions of the telomerase besides its major role in telomere maintenance. In our previous work, we have demonstrated that the hTERT can functionally interact with a rabbit TER to regulate expression of other genes and also attenuate the induced apoptosis. Here we report that overexpression of hTERT in a human lens epithelial cell line accelerates growth of the transfected lens epithelial cells. Associated with the acceleration of cell growth, expression of p53, p21 and GCIP (Grap2 cyclin-D interacting protein) is downregulated in the hTERT-transfected cells. With the downregulation of p21 and GCIP, the retinoblastoma protein (RB) is completely hyperphosphorylated in the hTERT-transfected cells. As expected, in the presence of RB hyperphosphorylation, the E2F transactivity is upregulated. Inhibition of telomerase activity abolishes the observed growth acceleration and also the related molecular changes. Furthermore, expression of hTERT in telomerase-negative human lens epithelial cells derived from primary cultures also accelerates growth of the transfected cells. Taken together, our results suggest that hTERT, when overexpressed in human lens epithelial cells, accelerates cell growth rate through regulation of RB/E2F pathway and possibly other genes.
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