ArticleOncogene2002
A novel tumour associated leucine zipper protein targeting to sites of gene transcription and splicing.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 48 citations in OpenAlex.
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- ADP-Ribosylation Post-Translational Modification: An Overview with a Focus on RNA Biology and New Pharmacological Perspectives.Biomolecules · 2022Review
- Systematic analysis of the function and prognostic value of RNA binding proteins in Colon Adenocarcinoma.Journal of Cancer · 2021Article
- Integrated Analysis of the Functions and Prognostic Values of RNA-Binding Proteins in Colorectal Cancer.Frontiers in cell and developmental biology · 2020Article
- Cancer-testis antigens in ovarian cancer: implication for biomarkers and therapeutic targets.Journal of ovarian research · 2019Review
- The role of TREX in gene expression and disease.The Biochemical journal · 2016Review
- IMP-3 promotes migration and invasion of melanoma cells by modulating the expression of HMGA2 and predicts poor prognosis in melanoma.The Journal of investigative dermatology · 2015Article
- Luzp4 defines a new mRNA export pathway in cancer cells.Nucleic acids research · 2015Article
- Differential gene expression profiling of enriched human spermatogonia after short- and long-term culture.BioMed research international · 2014Article
- EBV-transformed lymphoblastoid cell lines as vaccines against cancer testis antigen-positive tumors.Cancer immunology, immunotherapy : CII · 2013Article
- The biology of cancer testis antigens: putative function, regulation and therapeutic potential.Molecular oncology · 2011Article
- High expression of testes-specific protease 50 is associated with poor prognosis in colorectal carcinoma.PloS one · 2011Article
- Article
- Cancer/testis antigens and gametogenesis: a review and "brain-storming" session.Cancer cell international · 2005Article
- Strengths and weaknesses of EST-based prediction of tissue-specific alternative splicing.BMC genomics · 2004Article
- Identification of an antigenic peptide derived from the cancer-testis antigen NY-ESO-1 binding to a broad range of HLA-DR subtypes.Cancer immunology, immunotherapy : CII · 2004Article
- Identification of tumor antigens as potential target antigens for immunotherapy by serological expression cloning.Cancer immunology, immunotherapy : CII · 2004Review
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe here the definition and characterization of antigen CT-8/HOM-TES-85 encoded by a previously unknown gene and identified by serological expression screening using antibodies from a seminoma patient. Intriguingly, the leucine zipper region of CT-8/HOM-TES-85 shows an atypical amphipathy with clusters of hydrophobic residues that is exclusively shared by the N-myc proto-oncogene. CT-8/HOM-TES-85 gene is tightly silenced in normal tissues except for testis. However, it is frequently activated in human neoplasms of different types including lung cancer, ovarian cancer, melanoma and glioma. Endogenous as well as heterogeneously expressed CT-8/HOM-TES-85 targets predominantly to the nucleus forming a distinctive speckled pattern of nuclear dots arranged in macromolecular structures. By co-localization studies these speckles were identified as loci of transcriptional activity and splicing, suggesting that CT-8/HOM-TES-85 may be involved in these processes. The aberrant expression of CT-8/HOM-TES-85 in human neoplasms might therefore be involved in cancer associated alterations of transcriptional or post-transcriptional processes and thus may disclose new mechanisms involved in the manifestation of the cancer phenotype.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.