ArticleProceedings of the National Academy of Sciences of the United States of America2002
Induced instability of two Arabidopsis constitutive pathogen-response alleles.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 56 citations in OpenAlex.
- Transgenerational epigenetic inheritance during plant evolution and breeding.Trends in plant science · 2024Review
- YODA Kinase Controls a Novel Immune Pathway of Tomato Conferring Enhanced Disease Resistance to the BacteriumFrontiers in plant science · 2020Article
- Constitutive activity of the Arabidopsis MAP Kinase 3 confers resistance to Pseudomonas syringae and drives robust immune responses.Plant signaling & behavior · 2017Article
- Article
- Mendelian and non-Mendelian regulation of gene expression in maize.PLoS genetics · 2013Article
- Paramutagenicity of a p1 epiallele in maize.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2013Article
- A gain-of-function mutation in the Arabidopsis disease resistance gene RPP4 confers sensitivity to low temperature.Plant physiology · 2010Article
- RNAi-mediated down-regulation of DCL1 and AGO1 induces developmental changes in resynthesized Arabidopsis allotetraploids.The New phytologist · 2010Article
- Role of small RNAs in host-microbe interactions.Annual review of phytopathology · 2010Review
- Gene duplication and hypermutation of the pathogen Resistance gene SNC1 in the Arabidopsis bal variant.Genetics · 2009Article
- Phenotypic instability of Arabidopsis alleles affecting a disease Resistance gene cluster.BMC plant biology · 2008Article
- Article
- Comparison of rhizosphere bacterial communities in Arabidopsis thaliana mutants for systemic acquired resistance.Microbial ecology · 2008Article
- A cluster of disease resistance genes in Arabidopsis is coordinately regulated by transcriptional activation and RNA silencing.The Plant cell · 2007Article
- Transcriptionally silenced transgenes in maize are activated by three mutations defective in paramutation.Genetics · 2006Article
- Epigenetics and its implications for plant biology 2. The 'epigenetic epiphany': epigenetics, evolution and beyond.Annals of botany · 2006Review
- Article
- Vascular associated death1, a novel GRAM domain-containing protein, is a regulator of cell death and defense responses in vascular tissues.The Plant cell · 2004Article
- Article
- Salicylate accumulation inhibits growth at chilling temperature in Arabidopsis.Plant physiology · 2004Article
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paramutation is an example of a non-Mendelian-directed allelic interaction that results in the epigenetic alteration of one allele. We describe a paramutation-like interaction between two alleles, bal and cpr1-1 (constitutive expressor of PR genes 1), which map to a complex R-like gene cluster on Arabidopsis chromosome 4. Both alleles cause dwarfing and constitutive defense responses, similar to another dwarf variant, ssi1 (suppressor of SA-insensitivity 1). Previous work has demonstrated that the bal and ssi1 phenotypes are caused by overexpression of an R-like gene from the cluster, which activates an salicylic acid-dependent defense pathway. Here, we show that the cpr1-1 variant does not alter gene expression from the R-like gene cluster. The bal and cpr1-1 alleles did not complement each other in F(1) hybrids, but F(2) populations that segregated bal and cpr1-1 alleles contained plants with normal morphology at a frequency of 20%. By using molecularly marked bal and cpr1-1 lines, we found that the majority of the normal phenotypes were correlated with inheritance of an altered cpr1-1 allele. Our observation that cpr1-1 is a metastable allele suggests that cpr1-1 is an epigenetic allele. The cpr1-1 allele is the third candidate epigenetic allele originating from this R-like gene cluster, making the region a possible hotspot of epigenetic variation.
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