ArticleProceedings of the National Academy of Sciences of the United States of America2002
An Arabidopsis mutation in translation elongation factor 2 causes superinduction of CBF/DREB1 transcription factor genes but blocks the induction of their downstream targets under low temperatures.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.
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67 citing papers in PubMed, 1 synthesis or guideline pooled it, 160 citations in OpenAlex.
- The Brachypodium distachyon cold-acclimated plasma membrane proteome is primed for stress resistance.G3 (Bethesda, Md.) · 2021Pooled it
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- Deep Learning Enhances Precision of Citrullination Identification in Human and Plant Tissue Proteomes.Molecular & cellular proteomics : MCP · 2025Article
- NTRC and thioredoxins m1/m2 underpin the light acclimation of plants on proteome and metabolome levels.Plant physiology · 2024Article
- Genome-wide identification and expression analysis of the CBF transcription factor family inPlant signaling & behavior · 2023Article
- Proteome and Interactome Linked to Metabolism, Genetic Information Processing, and Abiotic Stress in Gametophytes of Two Woodferns.International journal of molecular sciences · 2023Article
- Calcium lignosulfonate modulates physiological and biochemical responses to enhance shoot multiplication inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2023Article
- Translational fidelity and growth of Arabidopsis require stress-sensitive diphthamide biosynthesis.Nature communications · 2022Article
- Using the Knowledge of Post-transcriptional Regulations to Guide Gene Selections for Molecular Breeding in Soybean.Frontiers in plant science · 2022Review
- Elevation of GhDREB1B transcription by a copy number variant significantly improves chilling tolerance in cotton.Planta · 2021Article
- Molecular Targets and Biological Functions of cAMP Signaling inBiomolecules · 2021Article
- The nucleolar protein SAHY1 is involved in pre-rRNA processing and normal plant growth.Plant physiology · 2021Article
- Genome-Wide Changes of Regulatory Non-Coding RNAs Reveal Pollen Development Initiated at Ecodormancy in Peach.Frontiers in molecular biosciences · 2021Article
- Arabidopsis ADF5 Acts as a Downstream Target Gene of CBFs in Response to Low-Temperature Stress.Frontiers in cell and developmental biology · 2021Article
- Construction of anti-codon table of the plant kingdom and evolution of tRNA selenocysteine (tRNABMC genomics · 2020Article
- Translational Components Contribute to Acclimation Responses to High Light, Heat, and Cold in Arabidopsis.iScience · 2020Article
- The SWI/SNF ATP-Dependent Chromatin Remodeling Complex in Arabidopsis Responds to Environmental Changes in Temperature-Dependent Manner.International journal of molecular sciences · 2020Article
- Eggplant Germination is Promoted by Hydrogen Peroxide and Temperature in an Independent but Overlapping Manner.Molecules (Basel, Switzerland) · 2019Article
- Physiology and proteomic analysis reveals root, stem and leaf responses to potassium deficiency stress in alligator weed.Scientific reports · 2019Article
- An eukaryotic elongation factor 2 from Medicago falcata (MfEF2) confers cold tolerance.BMC plant biology · 2019Article
7 more citing papers are in PubMed but not listed here.
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4 authors at 1 institution in 1 country.
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Abstract
Low temperature regulates gene expression in bacteria, yeast, and animals as well as in plants. However, the signal transduction cascades mediating the low temperature responses are not well understood in any organism. To identify components in low temperature signaling genetically, we isolated Arabidopsis thaliana mutants in which cold-responsive genes are no longer induced by low temperatures. One of these mutations, los1-1, specifically blocks low temperature-induced transcription of cold-responsive genes. Surprisingly, cold-induced expression of the early response transcriptional activators, C-repeat/dehydration responsive element binding factors (CBF/DREB1s), is enhanced by the los1-1 mutation. The los1-1 mutation also reduces the capacity of plants to develop freezing tolerance but does not impair the vernalization response. Genetic analysis indicated that los1-1 is a recessive mutation in a single nuclear gene. The LOS1 gene encodes a translation elongation factor 2-like protein. Protein labeling studies show that new protein synthesis is blocked in los1-1 mutant plants specifically in the cold. These results reveal a critical role of new protein synthesis in the proper transduction of low temperature signals. Our results also suggest that cold-induced transcription of CBF/DREB1s is feedback inhibited by their gene products or by products of their downstream target genes.
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