ArticleProceedings of the National Academy of Sciences of the United States of America2002
Opposing actions of adrenal androgens and glucocorticoids on alternative splicing of Slo potassium channels in bovine chromaffin cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 60 citations in OpenAlex.
- Large conductance voltage-and calcium-activated KFrontiers in pharmacology · 2024Review
- Calcium- and voltage-gated BK channels in vascular smooth muscle.Pflugers Archiv : European journal of physiology · 2018Review
- Large-conductance CaThe Journal of physiology · 2017Article
- Glucocorticoids Inhibit CRH/AVP-Evoked Bursting Activity of Male Murine Anterior Pituitary Corticotrophs.Endocrinology · 2016Article
- Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate.Nature communications · 2014Article
- Big Potassium (BK) ion channels in biology, disease and possible targets for cancer immunotherapy.International immunopharmacology · 2014Review
- The cochlea as an independent neuroendocrine organ: expression and possible roles of a local hypothalamic-pituitary-adrenal axis-equivalent signaling system.Hearing research · 2012Review
- The cochlear CRF signaling systems and their mechanisms of action in modulating cochlear sensitivity and protection against trauma.Molecular neurobiology · 2011Review
- Identification and quantification of full-length BK channel variants in the developing mouse cochlea.Journal of neuroscience research · 2011Article
- Selective expression in carotid body type I cells of a single splice variant of the large conductance calcium- and voltage-activated potassium channel confers regulation by AMP-activated protein kinase.The Journal of biological chemistry · 2011Article
- Upregulation of STREX splice variant of the large conductance Ca2+-activated potassium (BK) channel in a rat model of mesial temporal lobe epilepsy.Neuroscience research · 2011Article
- Ion channels and signaling in the pituitary gland.Endocrine reviews · 2010Review
- Hypertension of Kcnmb1-/- is linked to deficient K secretion and aldosteronism.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Effect of aldosterone on BK channel expression in mammalian cortical collecting duct.American journal of physiology. Renal physiology · 2008Article
- Control of alternative pre-mRNA splicing by Ca(++) signals.Biochimica et biophysica acta · 2008Review
- Dehydroepiandrosterone stimulates endothelial proliferation and angiogenesis through extracellular signal-regulated kinase 1/2-mediated mechanisms.Endocrinology · 2008Article
- Diabetes-induced changes in the alternative splicing of the slo gene in corporal tissue.European urology · 2007Article
- Alternatively spliced C-terminal domains regulate the surface expression of large conductance calcium-activated potassium channels.Neuroscience · 2007Article
- Age-dependent regulation of chromaffin cell proliferation by growth factors, dehydroepiandrosterone (DHEA), and DHEA sulfate.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Increased large conductance calcium-activated potassium (BK) channel expression accompanied by STREX variant downregulation in the developing mouse CNS.BMC developmental biology · 2006Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Pituitary ablation (hypophysectomy) in rats was previously reported to cause a precipitous change in the relative abundance of two alternative splice variants of the "BK"- or "Maxi K"-encoding Slo gene in adrenal chromaffin cells. Inclusion of the optional "STREX" exon (STRess axis-regulated EXon) in a C-terminal splice site was reduced, in preference to the variant lacking an insert at this site. Adrenocorticotropic hormone (ACTH) injections prevented the drop in STREX inclusion, implicating stress-axis function, as opposed to other pituitary functions. Because ACTH promotes synthesis and release of glucocorticoids (corticosterone or cortisol, depending on species), we hypothesized that glucocorticoids applied directly would promote STREX inclusion. Contrary to predictions, we report that direct application of glucocorticoids to bovine cells in vitro decreased STREX inclusion. This effect was blocked by the glucocorticoid receptor antagonist RU38486. As with glucocorticoids, synthesis and release of the adrenal androgen dehydroepiandrosterone (DHEA) increases in response to stress or elevated ACTH levels in some species. We report that direct application of DHEA increased expression of the STREX variant in cultured bovine cells. Two other androgens, androstenedione and testosterone, had similar effects. We hypothesize that Slo splicing in adrenal chromaffin cells in vivo is differentially regulated by the integrative, concentration- and time-dependent actions of glucocorticoids and androgens, with potentially important ramifications for stress-evoked catecholamine secretion.
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