ArticleProceedings of the National Academy of Sciences of the United States of America2002
Synergistic transcriptional activation by one regulatory protein in response to two metabolites.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 97 citations in OpenAlex.
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- Maleylpyruvic Acid-Inducible Gene Expression System and Its Application for the Development of Gentisic Acid Biosensors.Analytical chemistry · 2024Article
- Fundamentals and Exceptions of the LysR-type Transcriptional Regulators.ACS synthetic biology · 2024Review
- Regulation of tricarboxylate transport and metabolism inApplied and environmental microbiology · 2024Article
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- PsrA is a novel regulator contributes to antibiotic synthesis, bacterial virulence, cell motility and extracellular polysaccharides production in Serratia marcescens.Nucleic acids research · 2022Article
- Functional and structural analysis of catabolite control protein C that responds to citrate.Scientific reports · 2021Article
- Development of a genetic toolset for the highly engineerable and metabolically versatile Acinetobacter baylyi ADP1.Nucleic acids research · 2020Article
- Mechanism underlying autoinducer recognition in theThe Journal of biological chemistry · 2020Article
- Evolution-guided engineering of small-molecule biosensors.Nucleic acids research · 2020Article
- Engineering CatM, a LysR-Type Transcriptional Regulator, to Respond Synergistically to Two Effectors.Genes · 2019Article
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- Cell-Wall Recycling of the Gram-Negative Bacteria and the Nexus to Antibiotic Resistance.Chemical reviews · 2018Review
- Regulation of the aceI multidrug efflux pump gene in Acinetobacter baumannii.The Journal of antimicrobial chemotherapy · 2018Article
- Identification of a Small Molecule Activator for AphB, a LysR-Type Virulence Transcriptional Regulator in Vibrio cholerae.Biochemistry · 2017Article
- Metabolic pathway and cell adaptation mechanisms revealed through genomic, proteomic and transcription analysis of a Sphingomonas haloaromaticamans strain degrading ortho-phenylphenol.Scientific reports · 2017Article
- Malonate degradation inMicrobiology (Reading, England) · 2017Article
- PnpM, a LysR-Type Transcriptional Regulator Activates the Hydroquinone Pathway inFrontiers in microbiology · 2017Article
- Engineering prokaryotic transcriptional activators as metabolite biosensors in yeast.Nature chemical biology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BenM is a LysR-type bacterial transcriptional regulator that controls aromatic compound degradation in Acinetobacter sp. ADP1. Here, in vitro transcription assays demonstrated that two metabolites of aromatic compound catabolism, benzoate and cis,cis-muconate, act synergistically to activate gene expression. The level of BenM-regulated benA transcription was significantly higher in response to both compounds than the combined levels due to each alone. These compounds also were more effective together than they were individually in altering the DNase I footprint patterns of BenM-DNA complexes. This type of dual-inducer synergy provides great potential for rapid and large modulations of gene expression and may represent an important, and possibly widespread, feature of transcriptional control.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.