ArticleProceedings of the National Academy of Sciences of the United States of America2002
CD2 molecules redistribute to the uropod during T cell scanning: implications for cellular activation and immune surveillance.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
- Biophysical and Structural Features of αβT-Cell Receptor Mechanosensing: A Paradigmatic Shift in Understanding T-Cell Activation.Immunological reviews · 2025Review
- Revisiting T-cell adhesion molecules as potential targets for cancer immunotherapy: CD226 and CD2.Experimental & molecular medicine · 2024Review
- Apelin modulates inflammation and leukocyte recruitment in experimental autoimmune encephalomyelitis.Nature communications · 2024Article
- Stepwise progression of β-selection during T cell development involves histone deacetylation.Life science alliance · 2023Article
- LPA suppresses T cell function by altering the cytoskeleton and disrupting immune synapse formation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Characterization of mechanisms positioning costimulatory complexes in immune synapses.iScience · 2021Article
- Neonatal monocytes demonstrate impaired homeostatic extravasation into a microphysiological human vascular model.Scientific reports · 2020Article
- Identification of gene modules associated with survival of diffuse large B-cell lymphoma treated with CHOP-based chemotherapy.The pharmacogenomics journal · 2020Article
- CD2 Immunobiology.Frontiers in immunology · 2020Review
- αβ T Cell Receptor Mechanosensing Forces out Serial Engagement.Trends in immunology · 2018Review
- Mechanosensing drives acuity ofProceedings of the National Academy of Sciences of the United States of America · 2017Article
- DNA-based nanoparticle tension sensors reveal that T-cell receptors transmit defined pN forces to their antigens for enhanced fidelity.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Immune biomarkers are more accurate in prediction of survival in ulcerated than in non-ulcerated primary melanomas.Cancer immunology, immunotherapy : CII · 2015Article
- PLZF expression during colorectal cancer development and in normal colorectal mucosa according to body size, as marker of colorectal cancer risk.TheScientificWorldJournal · 2013Article
- Searching for "signal 2": costimulation requirements of γδ T cells.Cellular and molecular life sciences : CMLS · 2011Review
- Nucleocapsid promotes localization of HIV-1 gag to uropods that participate in virological synapses between T cells.PLoS pathogens · 2010Article
- Subcellular dynamics of T cell immunological synapses and kinapses in lymph nodes.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Bringing up the rear: defining the roles of the uropod.Nature reviews. Molecular cell biology · 2009Review
- Antigen-independent adhesion and cell spreading by inducible costimulator engagement inhibits T cell migration in a PI-3K-dependent manner.Journal of leukocyte biology · 2009Article
- Increased effector-target cell conjugate formation due to HLA restricted specific antigen recognition.Immunologic research · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Dynamic binding between CD2 and CD58 counter-receptors on opposing cells optimizes immune recognition through stabilization of cell-cell contact and juxtaposition of surface membranes at a distance suitable for T cell receptor-ligand interaction. Digitized time-lapse differential interference contrast and immunofluorescence microscopy on living cells now show that this binding also induces T cell polarization. Moreover, CD2 can facilitate motility of T cells along antigen-presenting cells via a movement referred to as scanning. Both activated CD4 and CD8 T cells are able to scan antigen-presenting cells surfaces in the absence of cognate antigen. Scanning is critically dependent on T cell beta-integrin function, as well as myosin light chain kinase. More importantly, surface CD2 molecules rapidly redistribute on interaction with a cellular substratum, resulting in a 100-fold greater CD2 density in the uropod versus the leading edge. In contrast, no redistribution is observed for CD11a/CD18 or CD45. Molecular compartmentalization of CD2, T cell receptor, and lipid rafts within the uropod prearranges the cellular activation machinery for subsequent immune recognition. This "presynapse" formation on primed T cells will likely facilitate the antigen-dependent recognition capability required for efficient immune surveillance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.