ArticleProceedings of the National Academy of Sciences of the United States of America2002
The crystal structure of the C-terminal fragment of striated-muscle alpha-tropomyosin reveals a key troponin T recognition site.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 87 citations in OpenAlex.
- Molecular Dynamics Assessment of Mechanical Properties of the Thin Filaments in Cardiac Muscle.International journal of molecular sciences · 2023Article
- High-resolution cryo-EM structure of the junction region of the native cardiac thin filament in relaxed state.PNAS nexus · 2023Article
- Impact of Troponin in Cardiomyopathy Development Caused by Mutations in Tropomyosin.International journal of molecular sciences · 2022Article
- Article
- Troponin Revealed: Uncovering the Structure of the Thin Filament On-Off Switch in Striated Muscle.Biophysical journal · 2021Review
- Functional outcomes of structural peculiarities of striated muscle tropomyosin.Journal of muscle research and cell motility · 2020Review
- Cardiomyopathy Mutation Alters End-to-End Junction of Tropomyosin and Reduces Calcium Sensitivity.Biophysical journal · 2020Article
- Docking Troponin T onto the Tropomyosin Overlapping Domain of Thin Filaments.Biophysical journal · 2020Article
- Structural and Dynamic Properties of Allergen and Non-Allergen Forms of Tropomyosin.Structure (London, England : 1993) · 2018Article
- Genotype-specific pathogenic effects in human dilated cardiomyopathy.The Journal of physiology · 2017Article
- Competition between Coiled-Coil Structures and the Impact on Myosin-10 Bundle Selection.Biophysical journal · 2016Article
- Recruitment Kinetics of Tropomyosin Tpm3.1 to Actin Filament Bundles in the Cytoskeleton Is Independent of Actin Filament Kinetics.PloS one · 2016Article
- Electrostatic interaction map reveals a new binding position for tropomyosin on F-actin.Journal of muscle research and cell motility · 2015Article
- Direct observation of tropomyosin binding to actin filaments.Cytoskeleton (Hoboken, N.J.) · 2015Article
- Phosphorylation of Ser283 enhances the stiffness of the tropomyosin head-to-tail overlap domain.Archives of biochemistry and biophysics · 2015Article
- Article
- Mechanism of the calcium-regulation of muscle contraction--in pursuit of its structural basis.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2015Review
- An atomic model of the tropomyosin cable on F-actin.Biophysical journal · 2014Article
- The structural dynamics of α-tropomyosin on F-actin shape the overlap complex between adjacent tropomyosin molecules.Archives of biochemistry and biophysics · 2014Article
- A Drosophila melanogaster model of diastolic dysfunction and cardiomyopathy based on impaired troponin-T function.Circulation research · 2014Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Contraction in striated and cardiac muscles is regulated by the motions of a Ca(2+)-sensitive tropomyosin/troponin switch. In contrast, troponin is absent in other muscle types and in nonmuscle cells, and actomyosin regulation is myosin-linked. Here we report an unusual crystal structure at 2.7 A of the C-terminal 31 residues of rat striated-muscle alpha-tropomyosin (preceded by a fragment of the GCN4 leucine zipper). The C-terminal 22 residues (263-284) of the structure do not form a two-stranded alpha-helical coiled coil as does the rest of the molecule, but here the alpha-helices splay apart and are stabilized by the formation of a tail-to-tail dimer with a symmetry-related molecule. The site of splaying involves a small group of destabilizing core residues that is present only in striated muscle tropomyosin isoforms. These results reveal a specific recognition site for troponin T and clarify the physical basis for the unique regulatory mechanism of striated muscles.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.