ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2002
Were vertebrates octoploid?
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
68 citing papers in PubMed.
- Article
- Forty new genomes shed light on sexual reproduction and the origin of tetraploidy in Microsporidia.PLoS biology · 2025Article
- A Class of Allopolyploidy Showing High Duplicate Retention and Continued Homoeologous Exchanges.Genome biology and evolution · 2025Article
- The genome sequence of the amphioxus,Wellcome open research · 2025Article
- Evidence of a Lytic Pathway in an Invertebrate Complement System: Identification of a Terminal Complement Complex Gene in a Colonial Tunicate and Its Evolutionary Implications.International journal of molecular sciences · 2024Article
- Demographic history inference and the polyploid continuum.Genetics · 2023Article
- Independent rediploidization masks shared whole genome duplication in the sturgeon-paddlefish ancestor.Nature communications · 2023Article
- Analysis of theCell genomics · 2023Article
- Article
- Early effects of gene duplication on the robustness and phenotypic variability of gene regulatory networks.BMC bioinformatics · 2022Article
- Review
- Parallel evolution of amphioxus and vertebrate small-scale gene duplications.Genome biology · 2022Article
- Genome-Wide Reconstruction of Rediploidization Following Autopolyploidization across One Hundred Million Years of Salmonid Evolution.Molecular biology and evolution · 2022Article
- Reconstruction of proto-vertebrate, proto-cyclostome and proto-gnathostome genomes provides new insights into early vertebrate evolution.Nature communications · 2021Article
- Evolutionary history of the human multigene families reveals widespread gene duplications throughout the history of animals.BMC evolutionary biology · 2019Article
- Phylogenetic analyses of human 1/2/8/20 paralogons suggest segmental duplications during animal evolution.3 Biotech · 2019Article
- Chromosome evolution at the origin of the ancestral vertebrate genome.Genome biology · 2018Article
- Linking autoimmunity to the origin of the adaptive immune system.Evolution, medicine, and public health · 2018Article
- The house spider genome reveals an ancient whole-genome duplication during arachnid evolution.BMC biology · 2017Article
- The evolutionary significance of polyploidy.Nature reviews. Genetics · 2017Review
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has long been suggested that gene and genome duplication play important roles in the evolution of organismal complexity. For example, work by Ohno proposed that two rounds of whole genome doubling (tetraploidy) occurred during the evolution of vertebrates: the extra genes permitting an increase in physiological and anatomical complexity. Several modifications of this 'two tetraploidies' hypothesis have been proposed, taking into account accumulating data, and there is wide acceptance of the basic scheme. In the past few years, however, several authors have raised doubts, citing lack of direct support or even evidence to the contrary. Here, we review the evidence for and against the occurrence of tetraploidies in early vertebrate evolution, and present a new compilation of molecular phylogenetic data for amphioxus. We argue that evidence in favour of tetraploidy, based primarily on genome and gene family analyses, is strong. Furthermore, we show that two observations used as evidence against genome duplication are in fact compatible with the hypothesis: but only if the genome doubling occurred by two closely spaced sequential rounds of autotetraploidy. We propose that early vertebrates passed through an autoautooctoploid phase in the evolution of their genomes.
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