ArticleProceedings. Biological sciences2002
Evolution of functionally conserved enhancers can be accelerated in large populations: a population-genetic model.
Article in Proceedings. Biological sciences, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Epistasis among clustered lineage-specific amino acid substitutions in the Drosophila Trio protein.PLoS genetics · 2026Article
- Evolutionary trade-off and mutational bias could favor transcriptional over translational divergence within paralog pairs.PLoS genetics · 2023Article
- Pairs of Mutually Compensatory Frameshifting Mutations Contribute to Protein Evolution.Molecular biology and evolution · 2022Article
- Regulatory mechanism predates the evolution of self-organizing capacity in simulated ant-like robots.Communications biology · 2019Article
- Passenger mutations can accelerate tumour suppressor gene inactivation in cancer evolution.Journal of the Royal Society, Interface · 2018Article
- Contingency and entrenchment in protein evolution under purifying selection.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- What does it take to evolve an enhancer? A simulation-based study of factors influencing the emergence of combinatorial regulation.Genome biology and evolution · 2015Article
- Cryptic genetic variation can make "irreducible complexity" a common mode of adaptation in sexual populations.Evolution; international journal of organic evolution · 2014Article
- Complex role of space in the crossing of fitness valleys by asexual populations.Journal of the Royal Society, Interface · 2014Article
- Naturally occurring deletions of hunchback binding sites in the even-skipped stripe 3+7 enhancer.PloS one · 2014Article
- Experiments on the role of deleterious mutations as stepping stones in adaptive evolution.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Patterns and evolution of ACGT repeat cis-element landscape across four plant genomes.BMC genomics · 2013Article
- Accelerated crossing of fitness valleys through division of labor and cheating in asexual populations.Scientific reports · 2012Article
- Article
- The rate of fitness-valley crossing in sexual populations.Genetics · 2010Article
- Scaling expectations for the time to establishment of complex adaptations.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- The rate of establishment of complex adaptations.Molecular biology and evolution · 2010Article
- Evolution of transcription factor binding sites in mammalian gene regulatory regions: handling counterintuitive results.Journal of molecular evolution · 2009Article
- The rate at which asexual populations cross fitness valleys.Theoretical population biology · 2009Article
- Evolution of the leukotoxin promoter in genus Mannheimia.BMC evolutionary biology · 2009Article
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2 authors.
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Abstract
The evolution of cis-regulatory elements (or enhancers) appears to proceed at dramatically different rates in different taxa. Vertebrate enhancers are often very highly conserved in their sequences, and relative positions, across distantly related taxa. In contrast, functionally equivalent enhancers in closely related Drosophila species can differ greatly in their sequences and spatial organization. We present a population-genetic model to explain this difference. The model examines the dynamics of fixation of pairs of individually deleterious, but compensating, mutations. As expected, small populations are predicted to have a high rate of evolution, and the rate decreases with increasing population size. In contrast to previous models, however, this model predicts that the rate of evolution by pairs of compensatory mutations increases dramatically for population sizes above several thousand individuals, to the point of greatly exceeding the neutral rate. Application of this model predicts that species with moderate population sizes will have relatively conserved enhancers, whereas species with larger populations will be expected to evolve their enhancers at much higher rates. We propose that the different degree of conservation seen in vertebrate and Drosophila enhancers may be explained solely by differences in their population sizes and generation times.
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