ArticleCell proliferation2002
Focal adhesion kinase tyrosine phosphorylation is associated with myogenesis and modulated by insulin.
Article in Cell proliferation, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Comparative Meta-Analysis of Transcriptomics Data during Cellular Senescence and In Vivo Tissue Ageing.Oxidative medicine and cellular longevity · 2015Pooled it
- Comparative Analysis of the Transcriptome of the Chicken Breast Muscle at Different Developmental Stages.Animals : an open access journal from MDPI · 2026Article
- FAK Signaling in Rhabdomyosarcoma.International journal of molecular sciences · 2020Review
- Genetic deletion of microRNA biogenesis in muscle cells reveals a hierarchical non-clustered network that controls focal adhesion signaling during muscle regeneration.Molecular metabolism · 2020Article
- The classic metal-sensing transcription factor MTF1 promotes myogenesis in response to copper.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Dynamic changes in copper homeostasis and post-transcriptional regulation of Atp7a during myogenic differentiation.Metallomics : integrated biometal science · 2018Article
- FAK tyrosine phosphorylation is regulated by AMPK and controls metabolism in human skeletal muscle.Diabetologia · 2018Article
- Focal adhesion kinase and its role in skeletal muscle.Journal of muscle research and cell motility · 2015Review
- The role of FAK in tumor metabolism and therapy.Pharmacology & therapeutics · 2014Review
- An alternate protocol for establishment of primary caprine fetal myoblast cell culture: an in vitro model for muscle growth study.In vitro cellular & developmental biology. Animal · 2013Article
- Focal adhesion kinase is required for IGF-I-mediated growth of skeletal muscle cells via a TSC2/mTOR/S6K1-associated pathway.American journal of physiology. Endocrinology and metabolism · 2013Article
- Immunofluorescent visualisation of focal adhesion kinase in human skeletal muscle and its associated microvasculature.Histochemistry and cell biology · 2012Article
- Protein tyrosine phosphatase-like A regulates myoblast proliferation and differentiation through MyoG and the cell cycling signaling pathway.Molecular and cellular biology · 2012Article
- Focal adhesion kinase signaling regulates the expression of caveolin 3 and beta1 integrin, genes essential for normal myoblast fusion.Molecular biology of the cell · 2009Article
- Focal adhesion kinase regulates insulin resistance in skeletal muscle.Diabetologia · 2007Article
- Role of protein kinase C during insulin mediated skeletal muscle cell spreading.Journal of muscle research and cell motility · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Focal adhesion kinase (FAK) was heavily phosphorylated as a function of differentiation of C2C12 mouse skeletal muscle cells. Insulin caused increases in FAK phosphorylation before stabilization in proliferated cells, while in differentiated cells there was a consistent transient inhibition of FAK phosphorylation before stimulation. The expression level of FAK was unaltered. Specific inhibition of insulin receptor tyrosine kinase activity abolished the insulin-mediated dephosphorylation of FAK. The data strongly indicate that FAK tyrosine phosphorylation, necessary for skeletal muscle differentiation, is modulated by insulin. Thus, for the first time, we report the differential regulation of FAK tyrosine phosphorylation by insulin during skeletal muscle differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.