ArticleMolecular and cellular biology2002
Xenopus LSm proteins bind U8 snoRNA via an internal evolutionarily conserved octamer sequence.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 54 citations in OpenAlex.
- White matter disorders at the intersection of transcription, RNA processing and translation.Nature reviews. Neurology · 2026Review
- U8 variants on the brain: a small nucleolar RNA and human disease.RNA biology · 2022Review
- Case Report: Clinical Features of Childhood Leukoencephalopathy With Cerebral Calcifications and Cysts Due toFrontiers in neurology · 2021Article
- Multiplexed Phosphoproteomic Study of Brain in Patients with Alzheimer's Disease and Age-Matched Cognitively Healthy Controls.Omics : a journal of integrative biology · 2020Article
- High-throughput transcriptome sequencing reveals extremely high doses of ionizing radiation-response genes inToxicology research · 2019Article
- Novel roles for Sm-class RNAs in the regulation of gene expression.RNA biology · 2018Review
- The sole LSm complex inRNA (New York, N.Y.) · 2017Article
- Mutations in SNORD118 cause the cerebral microangiopathy leukoencephalopathy with calcifications and cysts.Nature genetics · 2016Article
- Cytoplasmic LSM-1 protein regulates stress responses through the insulin/IGF-1 signaling pathway in Caenorhabditis elegans.RNA (New York, N.Y.) · 2015Article
- The Heptameric SmAP1 and SmAP2 Proteins of the Crenarchaeon Sulfolobus Solfataricus Bind to Common and Distinct RNA Targets.Life (Basel, Switzerland) · 2015Article
- Evolutionary conservation and expression of human RNA-binding proteins and their role in human genetic disease.Advances in experimental medicine and biology · 2014Review
- Arabidopsis thaliana LSM proteins function in mRNA splicing and degradation.Nucleic acids research · 2013Article
- Lsm proteins and Hfq: Life at the 3' end.RNA biology · 2013Review
- Archaeal and eukaryotic homologs of Hfq: A structural and evolutionary perspective on Sm function.RNA biology · 2013Review
- Experimental identification and analysis of macronuclear non-coding RNAs from the ciliate Tetrahymena thermophila.Nucleic acids research · 2012Article
- Transcriptional repressor NIR functions in the ribosome RNA processing of both 40S and 60S subunits.PloS one · 2012Article
- Article
- A small nucleolar RNA functions in rRNA processing in Caenorhabditis elegans.Nucleic acids research · 2010Article
- Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.Molecular and cellular biology · 2010Article
- The Drosophila U7 snRNP proteins Lsm10 and Lsm11 are required for histone pre-mRNA processing and play an essential role in development.RNA (New York, N.Y.) · 2009Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
U8 snoRNA plays a unique role in ribosome biogenesis: it is the only snoRNA essential for maturation of the large ribosomal subunit RNAs, 5.8S and 28S. To learn the mechanisms behind the in vivo role of U8 snoRNA, we have purified to near homogeneity and characterized a set of proteins responsible for the formation of a specific U8 RNA-binding complex. This 75-kDa complex is stable in the absence of added RNA and binds U8 with high specificity, requiring the conserved octamer sequence present in all U8 homologues. At least two proteins in this complex can be cross-linked directly to U8 RNA. We have identified the proteins as Xenopus homologues of the LSm (like Sm) proteins, which were previously reported to be involved in cytoplasmic degradation of mRNA and nuclear stabilization of U6 snRNA. We have identified LSm2, -3, -4, -6, -7, and -8 in our purified complex and found that this complex associates with U8 RNA in vivo. This purified complex can bind U6 snRNA in vitro but does not bind U3 or U14 snoRNA in vitro, demonstrating that the LSm complex specifically recognizes U8 RNA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.