ArticleBritish journal of pharmacology2002
Increased arginase activity underlies allergen-induced deficiency of cNOS-derived nitric oxide and airway hyperresponsiveness.
Article in British journal of pharmacology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 145 citations in OpenAlex.
- Regulatory haplotypes in ARG1 are associated with altered bronchodilator response.American journal of respiratory and critical care medicine · 2011Trial
- M-MDSCFrontiers in immunology · 2023Article
- Mini review: Neural mechanisms underlying airway hyperresponsiveness.Neuroscience letters · 2021Review
- An update on the diagnostic biomarkers for asthma.Journal of family medicine and primary care · 2021Review
- Arginine Therapy for Lung Diseases.Frontiers in pharmacology · 2021Review
- Pulmonary group 2 innate lymphoid cells: surprises and challenges.Mucosal immunology · 2019Review
- Association of increased risk of asthma with elevated arginase & interleukin-13 levels in serum & rs2781666 G/T genotype of arginase I.The Indian journal of medical research · 2018Article
- Arginase-1 Expression in Myeloid Cells Regulates Staphylococcus aureus Planktonic but Not Biofilm Infection.Infection and immunity · 2018Article
- GC/MS-Based Metabolomics Reveals Biomarkers in Asthma Murine Model Modulated byEvidence-based complementary and alternative medicine : eCAM · 2018Article
- Arginase 1 deletion in myeloid cells affects the inflammatory response in allergic asthma, but not lung mechanics, in female mice.BMC pulmonary medicine · 2017Article
- Soft TCPTP Agonism-Novel Target to Rescue Airway Epithelial Integrity by Exogenous Spermidine.Frontiers in pharmacology · 2016Article
- Is arginase a potential drug target in tobacco-induced pulmonary endothelial dysfunction?Respiratory research · 2015Article
- Novel therapeutic strategies for adult obese asthmatics.Immunology and allergy clinics of North America · 2014Review
- Arginase I levels are decreased in the plasma of pediatric patients with atopic dermatitis.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2014Article
- Asymmetric dimethylarginine in chronic obstructive pulmonary disease (ADMA in COPD).International journal of molecular sciences · 2014Article
- Modulation of the oscillatory mechanics of lung tissue and the oxidative stress response induced by arginase inhibition in a chronic allergic inflammation model.BMC pulmonary medicine · 2013Article
- Stimulated nitric oxide production and arginine deficiency in children with cystic fibrosis with nutritional failure.The Journal of pediatrics · 2013Article
- Anti-inflammatory effect of arginase inhibitor and corticosteroid on airway allergic reactions in a Dermatophogoides farinae-induced NC/Nga mouse model.Inflammation · 2013Article
- Integrative systems biology approaches in asthma pharmacogenomics.Pharmacogenomics · 2012Review
- L-citrulline supplementation reverses the impaired airway relaxation in neonatal rats exposed to hyperoxia.Respiratory research · 2012Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. A deficiency of constitutive nitric oxide synthase (cNOS)-derived nitric oxide (NO), due to reduced availability of L-arginine, importantly contributes to allergen-induced airway hyperresponsiveness (AHR) after the early asthmatic reaction (EAR). Since cNOS and arginase use L-arginine as a common substrate, we hypothesized that increased arginase activity is involved in the allergen-induced NO deficiency and AHR. 2. Using a guinea-pig model of allergic asthma, we addressed this hypothesis by examining the effects of the specific arginase inhibitor N(omega)-hydroxy-nor-L-arginine (nor-NOHA) on the responsiveness to methacholine of isolated perfused tracheae from unchallenged control animals and from animals 6 h after ovalbumin challenge. Arginase activity in these preparations was investigated by measuring the conversion of L-[14C]arginine to [14C]urea. 3. Airways from allergen-challenged animals showed a 2 fold (P<0.001) increase in responsiveness to intraluminal (IL) administration of methacholine compared to controls. A similar hyperresponsiveness (1.8 fold, P<0.01) was observed in control airways incubated with the NOS inhibitor N(omega)-nitro-L-arginine methyl ester (L-NAME, 0.1 mM, IL), while L-NAME had no further effect on the airways from challenged animals. 4. Remarkably, 5 microM nor-NOHA (IL) normalized the hyperresponsiveness of challenged airways to basal control (P<0.001), and this effect was fully reversed again by 0.1 mM L-NAME (P<0.05). Moreover, arginase activity in homogenates of the hyperresponsive airways was 3.5 fold (P<0.001) enhanced compared to controls. 5. The results indicate that enhanced arginase activity contributes to allergen-induced deficiency of cNOS-derived NO and AHR after the EAR, presumably by competition with cNOS for the common substrate, L-arginine. This is the first demonstration that arginase is involved in the pathophysiology of asthma.
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