ArticleBiophysical journal2002
The effect of ceramide on phosphatidylcholine membranes: a deuterium NMR study.
Article in Biophysical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 97 citations in OpenAlex.
- Long chain ceramides raise the main phase transition of monounsaturated phospholipids to physiological temperature.Scientific reports · 2022Article
- The role of ceramides in metabolic disorders: when size and localization matters.Nature reviews. Endocrinology · 2020Review
- Lamellar Phases Composed of Phospholipid, Cholesterol, and Ceramide, as Studied byBiophysical journal · 2019Article
- Lateral Segregation of Palmitoyl Ceramide-1-Phosphate in Simple and Complex Bilayers.Biophysical journal · 2019Article
- DHA Modifies the Size and Composition of Raftlike Domains: A Solid-StateBiophysical journal · 2018Article
- The many faces (and phases) of ceramide and sphingomyelin II - binary mixtures.Biophysical reviews · 2017Review
- Ceramide-C16 Is a Versatile Modulator of Phosphatidylethanolamine Polymorphism.Biophysical journal · 2017Article
- Bilayer Interactions among Unsaturated Phospholipids, Sterols, and Ceramide.Biophysical journal · 2017Article
- Lipid Interactions and Organization in Complex Bilayer Membranes.Biophysical journal · 2016Article
- Influence of Hydroxylation, Chain Length, and Chain Unsaturation on Bilayer Properties of Ceramides.Biophysical journal · 2015Article
- Ceramide-lipid interactions studied by MD simulations and solid-state NMR.Biochimica et biophysica acta · 2014Article
- Effects of lipid interactions on model vesicle engulfment by alveolar macrophages.Biophysical journal · 2014Article
- Effects of sphingomyelin headgroup size on interactions with ceramide.Biophysical journal · 2013Article
- Insights into sphingolipid miscibility: separate observation of sphingomyelin and ceramide N-acyl chain melting.Biophysical journal · 2012Article
- Importance of the sphingoid base length for the membrane properties of ceramides.Biophysical journal · 2012Article
- Mixing properties of sphingomyelin ceramide bilayers: a simulation study.The journal of physical chemistry. B · 2012Article
- Effects of sphingosine 2N- and 3O-methylation on palmitoyl ceramide properties in bilayer membranes.Biophysical journal · 2011Article
- Structural Versatility of Bicellar Systems and Their Possibilities as Colloidal Carriers.Pharmaceutics · 2011Article
- Cholesterol displaces palmitoylceramide from its tight packing with palmitoylsphingomyelin in the absence of a liquid-disordered phase.Biophysical journal · 2010Article
- Ceramide-rich platforms in transmembrane signaling.FEBS letters · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biological membranes contain domains having distinct physical properties. We study defined mixtures of phosphoglycerolipids and sphingolipids to ascertain the fundamental interactions governing these lipids in the absence of other cell membrane components. By using (2)H-NMR we have determined the temperature and composition dependencies of membrane structure and phase behavior for aqueous dispersions of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and the ceramide (Cer) N-palmitoyl-sphingosine. It is found that gel and liquid-crystalline phases coexist over a wide range of temperature and composition. Domains of different composition and phase state are present in POPC/Cer membranes at physiological temperature for Cer concentrations exceeding 15 mol %. The acyl chains of liquid crystalline phase POPC are ordered by the presence of Cer. Moreover, Cer's chain ordering is greater than that of POPC in the liquid crystalline phase. However, there is no evidence of liquid-liquid phase separation in the liquid crystalline region of the POPC/Cer phase diagram.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.