ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
Pancreatic elastase induces liver injury by activating cytokine production within Kupffer cells via nuclear factor-Kappa B.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 57 citations in OpenAlex.
- Liver-pancreas communication in disease and drug development.Acta pharmaceutica Sinica. B · 2026Review
- Prognostic value of the international normalized ratio to albumin ratio in acute pancreatitis: insights from MIMIC-IV database.BMC gastroenterology · 2025Article
- VMP1 Constitutive Expression in Mice Dampens Pancreatic and Systemic Histopathological Damage in an Experimental Model of Severe Acute Pancreatitis.International journal of molecular sciences · 2025Article
- Article
- Liver injury associated with acute pancreatitis: The current status of clinical evaluation and involved mechanisms.World journal of clinical cases · 2021Review
- Protective Mechanism of MIF Inhibitor ISO-1 on Intrahepatic Bile Duct Cells in Rats with Severe Acute Pancreatitis.Digestive diseases and sciences · 2021Article
- Intestinal bacterial overgrowth in the early stage of severe acute pancreatitis is associated with acute respiratory distress syndrome.World journal of gastroenterology · 2021Article
- Macrophage Migration Inhibitor Promoted the Intrahepatic Bile Duct Injury in Rats with Severe Acute Pancreatitis.Digestive diseases and sciences · 2019Article
- Autophagy, Inflammation, and Immune Dysfunction in the Pathogenesis of Pancreatitis.Gastroenterology · 2017Review
- Volume replacement with saline solutions during pancreatitis in rats and the hepatic profiles of apoptotic proteins and heat-shock proteins.Revista Brasileira de terapia intensiva · 2012Article
- Systemic inflammation with multiorgan dysfunction is the cause of death in murine ligation-induced acute pancreatitis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2011Article
- Role of macrophages in the progression of acute pancreatitis.World journal of gastrointestinal pharmacology and therapeutics · 2010Article
- A novel model of severe gallstone pancreatitis: murine pancreatic duct ligation results in systemic inflammation and substantial mortality.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2010Article
- Protein kinase C-zeta (PKC-zeta) regulates Kupffer cell apoptosis during experimental sepsis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2007Article
- Protein kinase C-zeta is critical in pancreatitis-induced apoptosis of Kupffer cells.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2007Article
- Influence of dexamethasone on inflammatory mediators and NF-kappaB expression in multiple organs of rats with severe acute pancreatitis.World journal of gastroenterology · 2007Article
- Fas/FasL play a central role in pancreatitis-induced hepatocyte apoptosis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2005Article
- Kupffer cell-derived Fas ligand plays a role in liver injury and hepatocyte death.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2004Article
- Effect of NF-kappaB and p38 MAPK in activated monocytes/macrophages on pro-inflammatory cytokines of rats with acute pancreatitis.World journal of gastroenterology · 2003Article
- Liver injury during acute pancreatitis: the role of pancreatitis-associated ascitic fluid (PAAF), p38-MAPK, and caspase-3 in inducing hepatocyte apoptosis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2003Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Liver injury is a manifestation of the systemic inflammatory response during acute pancreatitis. We have demonstrated that elastase induces macrophage tumor necrosis factor (TNF) production in distant organs, thus mimicking pancreatitis-associated organ injury. The aim of this study was to determine the mechanism by which elastase induces hepatic cytokine production. Rat livers (n = 40) were perfused with elastase +/- gadolinium (Gd) to inhibit Kupffer cells. Liver parenchymal enzymes and TNF were measured in the effluent. In vitro, rat hepatocytes or Kupffer cells were treated with elastase (1 U/ml) +/- Gd (0.5 mg/ml) or pyrrolidine dithiocarbamate (PDTC; 0.5 mg/ml). TNF protein, TNF messenger RNA, and NF-kappa B activation were determined. In vivo, Gd blunted the elastase-induced TNF production and decreased AST, ALT, LDH, and nonviable cells (propidium iodide) (P < or= 0.03 vs. elastase). In vitro, elastase induced TNF production from Kupffer cells (P < 0.001 vs. control) but not from hepatocytes. Gd or PDTC significantly attenuated the elastase-induced TNF production (P < 0.001). Elastase-induced overexpression of TNF messengerRNA and activation of NF-kappa B was attenuated by Gd. Pancreatic elastase induces a pattern of liver injury similar to that seen during acute pancreatitis by activating cytokine production and gene expression within Kupffer cells via NF-kappa B. Gd exhibits a protective effect against elastase-induced liver injury by inhibiting activation of NF-kappa B.
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