ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
Age-associated changes in gene expression patterns in the liver.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 56 citations in OpenAlex.
- Integrated chromatin and transcriptomic profiling reveals sex-specific mechanisms of gene regulation in hepatic nutrient responses.PLoS biology · 2026Article
- A computational framework for detecting inter-tissue gene-expression coordination changes with aging.Scientific reports · 2025Article
- voyAGEr, a free web interface for the analysis of age-related gene expression alterations in human tissues.eLife · 2024Article
- Hepatic Gene Expression of Angiogenic and Regeneration Markers in Cats with Congenital Portosystemic Shunts (CPSS).Veterinary sciences · 2024Article
- Gene expression profiles during postnatal development of the liver and pancreas in giant pandas.Aging · 2020Article
- Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases.International review of cell and molecular biology · 2018Review
- Article
- HDAC inhibitor-dependent transcriptome and memory reinstatement in cognitive decline models.The Journal of clinical investigation · 2015Article
- Age-related changes in mRNA levels of hepatic transporters, cytochrome P450 and UDP-glucuronosyltransferase in female rats.European journal of drug metabolism and pharmacokinetics · 2015Article
- Uncovering RNA binding proteins associated with age and gender during liver maturation.Scientific reports · 2015Article
- Induction of cell proliferation in old rat liver can reset certain gene expression levels characteristic of old liver to those associated with young liver.Age (Dordrecht, Netherlands) · 2013Article
- Loss of caspase-2 accelerates age-dependent alterations in mitochondrial production of reactive oxygen species.Biogerontology · 2013Article
- Probiotic Dahi containing Lactobacillus acidophilus and Bifidobacterium bifidum alleviates age-inflicted oxidative stress and improves expression of biomarkers of ageing in mice.Molecular biology reports · 2012Article
- Genome-wide patterns of gene expression during aging in the African malaria vector Anopheles gambiae.PloS one · 2010Article
- Identification of differentially expressed genes in the kidneys of growth hormone transgenic mice.Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2010Article
- Integrative and comparative genomics analysis of early hepatocellular carcinoma differentiated from liver regeneration in young and old.Molecular cancer · 2010Article
- The hepatic transcriptome in human liver disease.Comparative hepatology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Aging is one of the least clearly understood biological processes. Alteration of oxidation/reduction (redox) enzymes has been demonstrated with aging; however, a systematic analysis of expression patterns has not been performed. The liver plays a key role in homeostasis and detoxification; therefore alteration of hepatic gene expression with aging may affect outcome after surgery. The purpose of our study was to assess changes in gene expression patterns in aged livers from both rats and humans using gene array analysis. Total RNA was extracted from young (2-month-old) and aged (2-year-old) rat livers, as well as young (1-year-old) and aged (78-year-old) human livers. Gene expression patterns were compared using Affymetrix GeneChip arrays. The expression pattern of selected genes was confirmed by reverse transcription-polymerase chain reaction. A threefold or greater change in gene expression was noted in 582 genes in the aged rat livers and 192 genes in the aged human livers. Comparison of the genes that were increased with aging demonstrated some similar patterns of expression in the rat and human livers, particularly in members of the antioxidant family and the cytochrome P-450 genes. Our findings demonstrate changes in the expression pattern of genes in the liver with aging. Concomitant increases in the expression of important antioxidant and detoxifying genes were noted in the livers of both rats and humans. This induction pattern suggests a complex link between changing hepatic detoxification/redox capability and senescence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.