ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
Mechanisms of impaired gallbladder contractile response in chronic acalculous cholecystitis.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 27 citations in OpenAlex.
- What imaging modalities should be considered in suspected acute acalculous cholecystitis? A review of the evidence.Insights into imaging · 2025Review
- Association between fibrosis-4 index (FIB-4) and gallstones: an analysis of the NHANES 2017-2020 cross-sectional study.BMC gastroenterology · 2025Article
- Use of Gallbladder Width Measurement by Computed Tomography in the Diagnosis of Acute Cholecystitis.Diagnostics (Basel, Switzerland) · 2022Article
- Article
- Variants in motilin, somatostatin and their receptor genes and risk of biliary tract cancers and stones in Shanghai, China.Meta gene · 2014Article
- Pain provocation and low gallbladder ejection fraction with CCK cholescintigraphy are not predictive of chronic acalculous gallbladder disease symptom relief after cholecystectomy.Digestive diseases and sciences · 2014Article
- Laparoscopic cholecystectomy for biliary dyskinesia: correlation of preoperative cholecystokinin cholescintigraphy results with postoperative outcome.Surgical endoscopy · 2004Article
- Smooth muscle function and dysfunction in gallbladder disease.Current gastroenterology reports · 2004Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The mechanisms involved in the impaired gallbladder contractile response in chronic acalculous cholecystitis are unknown. To determine the mechanisms that may lead to impaired gallbladder emptying in chronic acalculous cholecystitis, gallbladder specimens removed during hepatic resection (controls) and after cholecystectomy for chronic acalculous cholecystitis were attached to force transducers and placed in tissue baths with oxygenated Krebs solution. Electrical field stimulation (EFS) (1 to 10 Hz, 0.1 msec, 70 V) or the contractile agonists, CCK-8 (10(-9) to 10(-5)) or K(+) (80 mmol/L), were placed separately in the tissue baths and changes in tension were determined. Patients with chronic acalculous cholecystitis had a mean gallbladder ejection fraction of 12% +/- 4%. Pathologic examination of all gallbladders removed for chronic acalculous cholecystitis revealed chronic cholecystitis. Spontaneous contractile activity was present in gallbladder strips in 83% of control specimens but only 29% of gallbladder strips from patients with chronic acalculous cholecystitis (P < 0.05 vs. controls). CCK-8 contractions were decreased by 54% and EFS-stimulated contractions were decreased by 50% in the presence of chronic acalculous cholecystitis (P < 0.05 vs. controls). K(+)-induced contractions were similar between control and chronic acalculous cholecystitis gallbladder strips. The impaired gallbladder emptying in chronic acalculous cholecystitis appears to be due to diminished spontaneous contractile activity and decreased contractile responsiveness to both CCK and EFS.
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