ArticleThe Biochemical journal2002
A novel role for farnesyl pyrophosphate synthase in fibroblast growth factor-mediated signal transduction.
Article in The Biochemical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 27 citations in OpenAlex.
- Article
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- Identification of Topping Responsive Proteins in Tobacco Roots.Frontiers in plant science · 2016Article
- Relevance Rank Platform (RRP) for Functional Filtering of High Content Protein-Protein Interaction Data.Molecular & cellular proteomics : MCP · 2015Article
- Development of genic SSR markers from transcriptome sequencing of pear buds.Journal of Zhejiang University. Science. B · 2014Article
- Abnormal gene expression in cerebellum of Npc1-/- mice during postnatal development.Brain research · 2010Article
- Gene expression of rat alveolar type II cells during hyperoxia exposure and early recovery.Free radical biology & medicine · 2007Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Farnesyl pyrophosphate synthase (FPPS) catalyses the formation of a key cellular intermediate in isoprenoid metabolic pathways. Here we describe a novel role for this enzyme in fibroblast growth factor (FGF)-mediated signalling. We demonstrate the binding of FPPS to FGF receptors (FGFRs) using the yeast two-hybrid assay, pull-down assays and co-immunoprecipitation. The interaction between FPPS and FGFR is regulated by the cellular metabolic state and by treatment with FGF-2. Overexpression of FPPS inhibits FGF-2-induced cell proliferation, accompanied by a failure of the FGF-2-mediated induction of cyclins D1 and E. Overexpression of FPPS in fibroblasts also promotes increased farnesylation of Ras, and temporally extends FGF-2-stimulated activation of the Ras/ERK (extracellular-signal-regulated kinase) cascade. These data suggest that, in addition to its role in isoprenoid biosynthesis, FPPS may function as a modulator of the cellular response to FGF treatment.
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Registered trials
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