ReviewInternational review of cytology2002
Photoreceptor renewal: a role for peripherin/rds.
Review in International review of cytology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 57 citations in OpenAlex.
- Ameboid Microglia as a Scavenger Role in Phagocytosis of Photoreceptor Outer Segment in an Experimental Retinal Detachment Model.Investigative ophthalmology & visual science · 2025Article
- Sub2Full: split spectrum to boost optical coherence tomography despeckling without clean data.Optics letters · 2024Article
- Article
- Rod photoreceptor-specific deletion of cytosolic aspartate aminotransferase, GOT1, causes retinal degeneration.Frontiers in ophthalmology · 2023Article
- Renormalization of metabolic coupling treats age-related degenerative disorders: an oxidative RPE niche fuels the more glycolytic photoreceptors.Eye (London, England) · 2022Review
- Hexokinase 2 is dispensable for photoreceptor development but is required for survival during aging and outer retinal stress.Cell death & disease · 2020Article
- Whole-genome sequences of Malawi cichlids reveal multiple radiations interconnected by gene flow.Nature ecology & evolution · 2018Article
- Usher syndrome type 1-associated cadherins shape the photoreceptor outer segment.The Journal of cell biology · 2017Article
- Photoreceptor discs form through peripherin-dependent suppression of ciliary ectosome release.The Journal of cell biology · 2017Article
- The exocyst and regulatory GTPases in urinary exosomes.Physiological reports · 2014Article
- Protein sorting, targeting and trafficking in photoreceptor cells.Progress in retinal and eye research · 2013Review
- A single valine residue plays an essential role in peripherin/rds targeting to photoreceptor outer segments.PloS one · 2013Article
- Sustained protection against photoreceptor degeneration in tubby mice by intravitreal injection of nanoceria.Biomaterials · 2012Article
- Cone outer segments: a biophysical model of membrane dynamics, shape retention, and lamella formation.Biophysical journal · 2012Article
- Structural and functional relationships between photoreceptor tetraspanins and other superfamily members.Cellular and molecular life sciences : CMLS · 2012Review
- Structural and functional protein network analyses predict novel signaling functions for rhodopsin.Molecular systems biology · 2011Article
- Outer segment oligomerization of Rds: evidence from mouse models and subcellular fractionation.Biochemistry · 2008Article
- Genetic supplementation of RDS alleviates a loss-of-function phenotype in C214S model of retinitis pigmentosa.Advances in experimental medicine and biology · 2008Article
- Mutations in the peripherin/RDS gene are an important cause of multifocal pattern dystrophy simulating STGD1/fundus flavimaculatus.The British journal of ophthalmology · 2007Article
- Effect of Rds abundance on cone outer segment morphogenesis, photoreceptor gene expression, and outer limiting membrane integrity.The Journal of comparative neurology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Visual transduction begins with the detection of light within the photoreceptor cell layer of the retina. Within this layer, specialized cells, termed rods and cones, contain the proteins responsible for light capture and its transduction to nerve impulses. The phototransductive proteins reside within an outer segment region that is connected to an inner segment by a thin stalk rich in cytoskeletal elements. A unique property of the outer segments is the presence of an elaborate intracellular membrane system that holds the phototransduction proteins and provides the requisite lipid environment. The maintenance of normal physiological function requires that these postmitotic cells retain the unique structure of the outer segment regions--stacks of membrane saccules in the case of rods and a continuous infolding of membrane in the case of cones. Both photoreceptor rod and cone cells achieve this through a series of coordinated steps. As new membranous material is synthesized, transported, and incorporated into newly forming outer segment membranes, a compensatory shedding of older membranous material occurs, thereby maintaining the segment at a constant length. These processes are collectively referred to as ROS (rod outer segment) or COS (cone outer segment) renewal. We review the cellular and molecular events responsible for these renewal processes and present the recent but compelling evidence, drawn from molecular genetic, biochemical, and biophysical approaches, pointing to an essential role for a unique tetraspanning membrane protein, called peripherin/rds, in the processes of disk morphogenesis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.