ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Sensory activation and role of inhibitory reticulospinal neurons that stop swimming in hatchling frog tadpoles.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 80 citations in OpenAlex.
- Article
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- From decision to action: Detailed modelling of frog tadpoles reveals neuronal mechanisms of decision-making and reproduces unpredictable swimming movements in response to sensory signals.PLoS computational biology · 2021Article
- Deep imaging in the brainstem reveals functional heterogeneity in V2a neurons controlling locomotion.Science advances · 2020Article
- A Neuronal Pathway that Commands Deceleration in Drosophila Larval Light-Avoidance.Neuroscience bulletin · 2019Article
- Growth at Cold Temperature Increases the Number of Motor Neurons to Optimize Locomotor Function.Current biology : CB · 2019Article
- Nervous mechanisms of locomotion in different directions.Current opinion in physiology · 2019Article
- Glutamatergic neurons of the gigantocellular reticular nucleus shape locomotor pattern and rhythm in the freely behaving mouse.PLoS biology · 2019Article
- A Brainstem Neural Substrate for Stopping Locomotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- To swim or not to swim: A population-level model of Xenopus tadpole decision making and locomotor behaviour.Bio Systems · 2017Article
- State-dependent sensorimotor gating in a rhythmic motor system.Journal of neurophysiology · 2017Article
- Supraspinal control of spinal reflex responses to body bending during different behaviours in lampreys.The Journal of physiology · 2017Article
- Integration of Descending Command Systems for the Generation of Context-Specific Locomotor Behaviors.Frontiers in neuroscience · 2017Review
- Modelling Feedback Excitation, Pacemaker Properties and Sensory Switching of Electrically Coupled Brainstem Neurons Controlling Rhythmic Activity.PLoS computational biology · 2016Article
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- Two knockdown models of the autism genes SYNGAP1 and SHANK3 in zebrafish produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis.Human molecular genetics · 2015Article
- Activity in descending dopaminergic neurons represents but is not required for leg movements in the fruit fly Drosophila.Physiological reports · 2015Article
- Behavioral observation of Xenopus tadpole swimming for neuroscience labs.Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2014Article
- Fusion of locomotor maneuvers, and improving sensory capabilities, give rise to the flexible homing strikes of juvenile zebrafish.Frontiers in neural circuits · 2013Article
- Removal of default state-associated inhibition during repetition priming improves response articulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Activity in neuronal networks underlying locomotion and other rhythmic actions can start and stop in response to specific sensory stimuli. In vertebrate locomotion, some reticulospinal neurons such as Mauthner neurons can initiate activity, but the neurons controlling stopping are not defined. We have studied swimming in tadpoles of the frog, Xenopus, which is started by touching the skin and stops when the head contacts a solid surface. Using an immobilized tadpole preparation, the same stimuli control fictive swimming. When head contact is imitated by pressure to the head skin sensory neurons in the trigeminal ganglion are active, spinal neurons receive GABAergic inhibition, and swimming stops. Here we record intracellularly from neurons in the hindbrain that are excited by pressure or electrical stimulation to the head skin. By intracellular filling with neurobiotin, we identify these anatomically as mid-hindbrain reticulospinal neurons (MHRs). These have contralateral descending projections to the spinal cord and GABA-like immunoreactivity. They are rhythmically inhibited during fictive swimming. Individual MHRs reliably stopped ongoing swimming when brief firing was induced by intracellular current injection. The ability of individual MHRs to stop swimming was blocked by the GABA(A) antagonist bicuculline. Our evidence indicates that MHRs receive direct excitation from trigeminal sensory neurons and in turn release GABA to directly inhibit spinal neurons and turn off the swimming central pattern generator.
Indexed as
Identifiers
12019340PMC6757637W2160648569What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.