ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Extracellular peptidase activity tunes motor pattern modulation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 35 citations in OpenAlex.
- Feeding state-specific hormonal tuning of neural circuit modulation.Journal of neurophysiology · 2025Article
- Neuropeptide inactivation regulates egg-laying behavior to influence reproductive health in Caenorhabditis elegans.Current biology : CB · 2024Article
- Neural circuit regulation by identified modulatory projection neurons.Frontiers in neuroscience · 2023Review
- Neuropeptide System Regulation of Prefrontal Cortex Circuitry: Implications for Neuropsychiatric Disorders.Frontiers in neural circuits · 2022Review
- Mass Spectrometry Quantification, Localization, and Discovery of Feeding-Related Neuropeptides inACS chemical neuroscience · 2021Article
- Aplysia allatotropin-related peptide and its newly identified d-amino acid-containing epimer both activate a receptor and a neuronal target.The Journal of biological chemistry · 2018Article
- General Principles of Neuronal Co-transmission: Insights From Multiple Model Systems.Frontiers in neural circuits · 2018Review
- Functional consequences of neuropeptide and small-molecule co-transmission.Nature reviews. Neuroscience · 2017Review
- Neuropeptide modulation of pattern-generating systems in crustaceans: comparative studies and approaches.Current opinion in neurobiology · 2016Review
- An extrasynaptic GABAergic signal modulates a pattern of forward movement in Caenorhabditis elegans.eLife · 2016Article
- Optical imaging of neuronal activity and visualization of fine neural structures in non-desheathed nervous systems.PloS one · 2014Article
- Neuropeptide modulation of microcircuits.Current opinion in neurobiology · 2012Review
- Discovery and functional study of a novel crustacean tachykinin neuropeptide.ACS chemical neuroscience · 2011Article
- Beyond the wiring diagram: signalling through complex neuromodulator networks.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- Presynaptic inhibition selectively weakens peptidergic cotransmission in a small motor system.Journal of neurophysiology · 2009Article
- Neuropeptide signaling near and far: how localized and timed is the action of neuropeptides in brain circuits?Invertebrate neuroscience : IN · 2009Review
- Modulation of stomatogastric rhythms.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2009Review
- A newly identified extrinsic input triggers a distinct gastric mill rhythm via activation of modulatory projection neurons.The Journal of experimental biology · 2008Article
- Convergent motor patterns from divergent circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Proctolin in the post-genomic era: new insights and challenges.Invertebrate neuroscience : IN · 2004Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We are examining how extracellular peptidase activity sculpts the peptidergic actions of modulatory projection neurons on rhythmically active neuronal circuits, using the pyloric circuit in the stomatogastric ganglion (STG) of the crab Cancer borealis. Neurally released peptides can diffuse long distances to bind to their receptors. Hence, different neurons releasing the same neuropeptide into the same neuropil may reach the same receptor complement. However, extracellular peptidases can limit neuropeptide diffusion and terminate its actions. Distinct versions of the pyloric rhythm are elicited by selective activation of different projection neurons, including those with overlapping sets of cotransmitters. Two of these projection neurons, modulatory commissural neuron 1 (MCN1) and the modulatory proctolin neuron (MPN), contain the neuropeptide proctolin plus GABA. MCN1 also contains Cancer borealis tachykinin-related peptide Ia (CabTRP Ia). CabTRP Ia is not fully responsible for the distinct actions of MCN1 and MPN. Because there is aminopeptidase activity in the STG that terminates proctolin actions, we tested the hypothesis that the differences in the actions of MCN1 and MPN that are not mediated by CabTRP Ia result from the differential actions of aminopeptidase activity on proctolin released from these two projection neurons. We found that the pyloric circuit response to these two projection neurons becomes more similar when this aminopeptidase activity is blocked. This result supports the hypothesis that extracellular peptidase activity enables different projection neurons to use the same neuropeptide transmitter for eliciting distinct outputs from the same neuronal circuit.
Indexed as
Identifiers
12019336PMC6757626W2120254090What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.