ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Nitric oxide selectively tunes inhibitory synapses to modulate vertebrate locomotion.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- Novel Insights on Nitric Oxide Synthase and NO Signaling in Ascidian Metamorphosis.International journal of molecular sciences · 2022Article
- Bimodal modulation of short-term motor memory via dynamic sodium pumps in a vertebrate spinal cord.Current biology : CB · 2022Article
- Nitric oxide mediates activity-dependent change to synaptic excitation during a critical period in Drosophila.Scientific reports · 2021Article
- Nitric oxide mediates neuro-glial interaction that shapes Drosophila circadian behavior.PLoS genetics · 2020Article
- Nitric oxide-mediated intersegmental modulation of cycle frequency in the crayfish swimmeret system.Biology open · 2018Article
- Developmental changes in spinal neuronal properties, motor network configuration, and neuromodulation at free-swimming stages of Xenopus tadpoles.Journal of neurophysiology · 2018Article
- A behaviorally related developmental switch in nitrergic modulation of locomotor rhythmogenesis in larval Xenopus tadpoles.Journal of neurophysiology · 2016Article
- Nitric oxide-mediated modulation of the murine locomotor network.Journal of neurophysiology · 2014Article
- How do short-term changes at synapses fine-tune information processing?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Review
- Gating the polarity of endocannabinoid-mediated synaptic plasticity by nitric oxide in the spinal locomotor network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Article
- Neurochemical architecture of the central complex related to its function in the control of grasshopper acoustic communication.PloS one · 2011Article
- The nitric oxide/cGMP pathway tunes the thermosensitivity of swimming motor patterns in Xenopus laevis tadpoles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Nitric oxide potentiation of locomotor activity in the spinal cord of the lamprey.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Suppression of spreading depression-like events in locusts by inhibition of the NO/cGMP/PKG pathway.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Long-term plasticity of the spinal locomotor circuitry mediated by endocannabinoid and nitric oxide signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Characterization of NO/cGMP-mediated responses in identified motoneurons.Cellular and molecular neurobiology · 2007Article
- Nitric oxide stimulates gamma-aminobutyric acid release and inhibits glycine release in retina.The Journal of comparative neurology · 2005Article
- Metamodulation of a spinal locomotor network by nitric oxide.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Regulation of neuronal proliferation and differentiation by nitric oxide.Molecular neurobiology · 2003Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We have explored the possible modulation by nitric oxide (NO) of inhibitory synaptic transmission mediated by either glycine or GABA during episodes of rhythmic fictive swimming in postembryonic Xenopus laevis tadpoles. Extracellular ventral-root recordings suggest a stage-dependent increase in the reliability and extent of the NO donor S-nitroso-n-acetylpenicillamine (SNAP; 0.1-1 mm) to inhibit swimming by reducing the frequency and shortening the duration of swim episodes. These effects of SNAP on the swimming rhythm at both developmental stages are corroborated by intracellular recordings from presumed motor neurons with sharp microelectrodes, which also suggest that NO inhibits swimming by facilitating both glycinergic and GABAergic inhibition. However, we found no evidence for NO modulation of the excitatory drive for swimming. In addition to presynaptic effects on inhibitory transmitter release, a pronounced postsynaptic membrane depolarization ( approximately 5-10 mV) and conductance decrease ( approximately 10-20%) are associated with bath application of SNAP. Hence, NO exerts inhibitory effects on swimming through multiple but selective actions on both the electrical properties of spinal neurons and on particular synaptic interconnections. The presynaptic and postsynaptic effects of NO act in concert to tune inhibitory synapses.
Indexed as
Identifiers
12019335PMC6757640W1902151978What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.