ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Modulation of Drosophila slowpoke calcium-dependent potassium channel activity by bound protein kinase a catalytic subunit.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Genetic Dissection of Aversive Associative Olfactory Learning and Memory in Drosophila Larvae.PLoS genetics · 2016Article
- Article
- SLOB, a SLOWPOKE channel binding protein, regulates insulin pathway signaling and metabolism in Drosophila.PloS one · 2011Article
- Identification of a neural circuit that underlies the effects of octopamine on sleep:wake behavior.Neuron · 2010Article
- Dynamics of learning-related cAMP signaling and stimulus integration in the Drosophila olfactory pathway.Neuron · 2009Article
- Supramolecular assemblies and localized regulation of voltage-gated ion channels.Physiological reviews · 2009Review
- Acute alcohol tolerance is intrinsic to the BKCa protein, but is modulated by the lipid environment.The Journal of biological chemistry · 2008Article
- MaxiK channel partners: physiological impact.The Journal of physiology · 2006Review
- Distinct stoichiometry of BKCa channel tetramer phosphorylation specifies channel activation and inhibition by cAMP-dependent protein kinase.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Regulation of an Aplysia bag-cell neuron cation channel by closely associated protein kinase A and a protein phosphatase.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Assembly of a Ca2+-dependent BK channel signaling complex by binding to beta2 adrenergic receptor.The EMBO journal · 2004Article
- Postsynaptic protein kinase A reduces neuronal excitability in response to increased synaptic excitation in the Drosophila CNS.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drosophila Slowpoke (dSlo) calcium-dependent potassium channels bind directly to the catalytic subunit of cAMP-dependent protein kinase (PKAc). We demonstrate here that coexpression of PKAc with dSlo in mammalian cells results in a dramatic decrease of dSlo channel activity. This modulation requires catalytically active PKAc but is not mediated by phosphorylation of S942, the only PKA consensus site in the dSlo C-terminal domain. dSlo binds to free PKAc but not to the PKA holoenzyme that includes regulatory subunits and is inactive. Activators of endogenous PKA that stimulate dSlo phosphorylation, but do not produce detectable PKAc binding to dSlo, do not modulate channel function. Furthermore, the catalytically inactive PKAc mutant does bind to dSlo but does not modulate channel activity. These results are consistent with the hypothesis that both binding of active PKAc to dSlo and phosphorylation of dSlo or some other protein are necessary for channel modulation.
Indexed as
Identifiers
12019304PMC6757639W1949796519What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.