ArticleGenetics2002
HET-E and HET-D belong to a new subfamily of WD40 proteins involved in vegetative incompatibility specificity in the fungus Podospora anserina.
Article in Genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44 citing papers in PubMed, 89 citations in OpenAlex.
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- Phylogenomics and adaptive evolution of the Colletotrichum gloeosporioides species complex.Communications biology · 2025Article
- What are the 100 most cited fungal genera?Studies in mycology · 2024Article
- het-B allorecognition in Podospora anserina is determined by pseudo-allelic interaction of genes encoding a HET and lectin fold domain protein and a PII-like protein.PLoS genetics · 2024Article
- Genome sequence and annotation of Periconia digitata a hopeful biocontrol agent of phytopathogenic oomycetes.Scientific data · 2023Article
- Emergence of the fungal immune system.iScience · 2023Review
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- Exploring a diverse world of effector domains and amyloid signaling motifs in fungal NLR proteins.PLoS computational biology · 2022Article
- Genome sequences of 24 Aspergillus niger sensu stricto strains to study strain diversity, heterokaryon compatibility, and sexual reproduction.G3 (Bethesda, Md.) · 2022Article
- Allorecognition genes drive reproductive isolation in Podospora anserina.Nature ecology & evolution · 2022Article
- Characterization of Vegetative Incompatibility inFrontiers in microbiology · 2022Article
- Article
- WD40 Repeat Proteins: Signalling Scaffold with Diverse Functions.The protein journal · 2018Review
- Drivers of genetic diversity in secondary metabolic gene clusters within a fungal species.PLoS biology · 2017Article
- Molecular Mechanisms Regulating Cell Fusion and Heterokaryon Formation in Filamentous Fungi.Microbiology spectrum · 2017Review
- Exploring the genomic diversity of black yeasts and relatives (Studies in mycology · 2017Article
- A TALE-inspired computational screen for proteins that contain approximate tandem repeats.PloS one · 2017Article
- A WDR Gene Is a Conserved Member of a Chitin Synthase Gene Cluster and Influences the Cell Wall in Aspergillus nidulans.International journal of molecular sciences · 2016Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vegetative incompatibility, which is very common in filamentous fungi, prevents a viable heterokaryotic cell from being formed by the fusion of filaments from two different wild-type strains. Such incompatibility is always the consequence of at least one genetic difference in specific genes (het genes). In Podospora anserina, alleles of the het-e and het-d loci control heterokaryon viability through genetic interactions with alleles of the unlinked het-c locus. The het-d2(Y) gene was isolated and shown to have strong similarity with the previously described het-e1(A) gene. Like the HET-E protein, the HET-D putative protein displayed a GTP-binding domain and seemed to require a minimal number of 11 WD40 repeats to be active in incompatibility. Apart from incompatibility specificity, no other function could be identified by disrupting the het-d gene. Sequence comparison of different het-e alleles suggested that het-e specificity is determined by the sequence of the WD40 repeat domain. In particular, the amino acids present on the upper face of the predicted beta-propeller structure defined by this domain may confer the incompatible interaction specificity.
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