ArticleAntimicrobial agents and chemotherapy2002
Impact of N-chlorotaurine on viability and production of secreted aspartyl proteinases of Candida spp.
Article in Antimicrobial agents and chemotherapy, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Tolerability of N-chlorotaurine plus ammonium chloride in the rabbit and human eye--a phase 1 clinical study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2008Trial
- Sequence Variation of Candida albicans Sap2 Enhances Fungal Pathogenicity via Complement Evasion and Macrophage M2-Like Phenotype Induction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- N-chlorotaurine is highly active against respiratory viruses including SARS-CoV-2 (COVID-19)Emerging microbes & infections · 2022Article
- Comparative Fungicidal Activities of N-Chlorotaurine and Conventional Antiseptics againstJournal of fungi (Basel, Switzerland) · 2022Article
- Current Opinion on the Therapeutic Capacity of Taurine-Containing Halogen Derivatives in Infectious and Inflammatory Diseases.Advances in experimental medicine and biology · 2022Review
- Activity ofAntibiotics (Basel, Switzerland) · 2021Article
- N-Chlorotaurine, a Promising Future Candidate for Topical Therapy of Fungal Infections.Mycopathologia · 2018Review
- Article
- Bactericidal and Fungicidal Activity ofAntimicrobial agents and chemotherapy · 2017Article
- N-Chlorotaurine Exhibits Fungicidal Activity against Therapy-Refractory Scedosporium Species and Lomentospora prolificans.Antimicrobial agents and chemotherapy · 2015Article
- N-chloramines, a promising class of well-tolerated topical anti-infectives.Antimicrobial agents and chemotherapy · 2013Review
- NVC-422 inactivates Staphylococcus aureus toxins.Antimicrobial agents and chemotherapy · 2013Article
- N-chlorotaurine, a long-lived oxidant produced by human leukocytes, inactivates Shiga toxin of enterohemorrhagic Escherichia coli.PloS one · 2012Article
- Tolerability of inhaled N-chlorotaurine in an acute pig streptococcal lower airway inflammation model.BMC infectious diseases · 2011Article
- Chemical characterization and biological properties of NVC-422, a novel, stable N-chlorotaurine analog.Antimicrobial agents and chemotherapy · 2011Article
- Basidiomycete metabolites attenuate virulence properties of Candida albicans in vitro.Mycoses · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
N-Chlorotaurine, an endogenous long-lived oxidant, demonstrated fungicidal activity against Candida spp. and a postantifungal effect. Secreted aspartyl proteinases, important fungal virulence factors, proved to be a first target of impact. These results provide support for the topical application of N-chlorotaurine as an antimicrobial agent in yeast infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.