Evidence map›Paper›PMID 12019118›Full record

ArticleAntimicrobial agents and chemotherapy2002

Amphotericin B formulations exert additive antifungal activity in combination with pulmonary alveolar macrophages and polymorphonuclear leukocytes against Aspergillus fumigatus.

Emmanuel Roilides, Caron A Lyman, Joanna Filioti, Onome Akpogheneta, Tin Sein, Cristina Gil Lamaignere, Ruta Petraitiene, Thomas J Walsh

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Pulmonary surfactant impacts in vitro activity of selected antifungal drugs against Candida krusei and Candida albicans.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024
    Article
  2. Article
  3. Liposomal amphotericin B-the future.The Journal of antimicrobial chemotherapy · 2022
    Article
  4. Frontiers in microbiology · 2020
    Article
  5. Preclinical Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Antifungal Activity of Liposomal Amphotericin B.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Combination treatment of invasive fungal infections.Clinical microbiology reviews · 2005
    Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Emmanuel Roilides3rd Department of Pediatrics, University of Thessaloniki, Hippokration Hospital, Thessaloniki GR-54642, Greece.
Caron A Lyman
Joanna Filioti
Onome Akpogheneta
Tin Sein
Cristina Gil Lamaignere
Ruta Petraitiene
Thomas J Walsh

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deoxycholate amphotericin B (DAMB) and amphotericin B lipid complex (ABLC) additively augmented the fungicidal activity of pulmonary alveolar macrophages against the conidia of Aspergillus fumigatus. DAMB, ABLC, and liposomal amphotericin B similarly displayed additive effects with polymorphonuclear leukocytes in damaging the hyphal elements of A. fumigatus.

Indexed as

Amphotericin BAnimalsAntifungal AgentsAspergillus fumigatusBronchoalveolar Lavage FluidColony Count, MicrobialExcipientsFemaleHumansIn Vitro TechniquesLipidsLiposomesMacrophages, AlveolarNeutrophilsPhagocytosisRabbitsAmphotericin BAntifungal AgentsExcipientsLipidsLiposomes

Identifiers

PMID12019118
PMCPMC127213

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.