ArticleAntimicrobial agents and chemotherapy2002
Characterization of variant Salmonella genomic island 1 multidrug resistance regions from serovars Typhimurium DT104 and Agona.
Article in Antimicrobial agents and chemotherapy, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
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79 citing papers in PubMed, 206 citations in OpenAlex.
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- Conjugative IncC Plasmid Entry Triggers the SOS Response and Promotes Effective Transfer of the Integrative Antibiotic Resistance Element SGI1.Microbiology spectrum · 2023Article
- Salmonella Genomic Island 1 requires a self-encoded small RNA for mobilization.Molecular microbiology · 2021Article
- Crucial role of Salmonella genomic island 1 master activator in the parasitism of IncC plasmids.Nucleic acids research · 2021Article
- IncC helper dependent plasmid-like replication of Salmonella Genomic Island 1.Nucleic acids research · 2021Article
- Genomic Analysis ofFrontiers in cellular and infection microbiology · 2021Article
- Highly clonal relationship among Salmonella Enteritidis isolates in a commercial chicken production chain, Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- Global phylogenomics of multidrug-resistant Salmonella enterica serotype Kentucky ST198.Microbial genomics · 2019Article
- Characterization of the emerging multidrug-resistant Salmonella enterica serovar Indiana strains in China.Emerging microbes & infections · 2019Article
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- Prediction of Phenotypic Antimicrobial Resistance Profiles From Whole Genome Sequences of Non-typhoidalFrontiers in microbiology · 2018Article
- Identification and Characterization of New Resistance-Conferring SGI1s (Frontiers in microbiology · 2018Article
- Salmonella genomic island 1 (SGI1) reshapes the mating apparatus of IncC conjugative plasmids to promote self-propagation.PLoS genetics · 2017Article
- Bacteriophages Contribute to the Spread of Antibiotic Resistance Genes among Foodborne Pathogens of theFrontiers in microbiology · 2017Review
- Genome Sequencing Reveals the Complex Polysaccharide-Degrading Ability of Novel Deep-Sea BacteriumFrontiers in microbiology · 2017Article
- Global Genomic Epidemiology of Salmonella enterica Serovar Typhimurium DT104.Applied and environmental microbiology · 2016Article
- Unmasking the ancestral activity of integron integrases reveals a smooth evolutionary transition during functional innovation.Nature communications · 2016Article
19 more citing papers are in PubMed but not listed here.
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4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Strains of multidrug-resistant Salmonella enterica serovar Typhimurium DT104 (DT104) and S. enterica serovar Agona (Agona) have been found to harbor Salmonella genomic island 1 (SGI1), a 43-kb genomic region that contains many of the drug resistance genes. Such strains are resistant to ampicillin (pse-1), chloramphenicol/florfenicol (floR), streptomycin/spectinomycin (aadA2), sulfonamides (sul1), and tetracycline [tet(G)] (commonly called the ACSSuT phenotype). All five resistance genes are found in a 13-kb multidrug resistance (MDR) region consisting of an unusual class I integron structure related to In4. We examined DT104 and Agona strains that exhibited other resistance phenotypes to determine if the resistance genes were associated with variant SGI1 MDR regions. All strains were found to harbor variant SGI1-like elements by using a combination of Southern hybridization, PCR mapping, and sequencing. Variant SGI1-like elements were found with MDR regions consisting of (i) an integron consisting of the SGI1 MDR region with the addition of a region containing a putative transposase gene (orf513) and dfrA10 located between duplicated qacEDelta1/sulI genes (SGI1-A; ACSSuTTm); (ii) an integron with either an aadA2 (SSu) or a pse-1 (ASu) cassette (SGI1-C and SGI1-B, respectively); (iii) an integron consisting of the SGI1-C MDR region plus an orf513/dfrA10 region as in SGI1-A (SGI1-D; ASSuTm; ampicillin resistance due to a TEM beta-lactamase); and (iv) an integron related to that in SGI1 but which contains a 10-kb inversion between two copies of IS6100, one which is inserted in floR (SGI1-E; ASSuT). We hypothesize that the MDR of SGI1 is subject to recombinational events that lead to the various resistance phenotypes in the Salmonella strains in which it is found.
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