ArticleDigestive diseases and sciences2002
Glucagon-like peptide 2 stimulates intestinal epithelial proliferation in vitro.
Article in Digestive diseases and sciences, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 52 citations in OpenAlex.
- Dietary β-glucan supplementation mitigates heat stress-induced impairment of performance, egg quality, and intestinal integrity in laying hens.Veterinary world · 2026Article
- Enteroendocrine Cells: Sensing Gut Microbiota and Regulating Inflammatory Bowel Diseases.Inflammatory bowel diseases · 2020Review
- Effects of different starch source of starter on small intestinal growth and endogenous GLP-2 secretion in preweaned lambs.Journal of animal science · 2018Article
- Effect of spineless cactus intake (Opuntia ficus-indica) on blood glucose levels in lactating sows and its impact on feed intake, body weight loss, and weaning-estrus interval.Tropical animal health and production · 2017Article
- Impact of Dietary Fibers on Nutrient Management and Detoxification Organs: Gut, Liver, and Kidneys.Advances in nutrition (Bethesda, Md.) · 2016Review
- Glucagon-like peptide-2 protects impaired intestinal mucosal barriers in obstructive jaundice rats.World journal of gastroenterology · 2015Article
- Effect of Glucagon-like Peptide 2 on Tight Junction in Jejunal Epithelium of Weaned Pigs though MAPK Signaling Pathway.Asian-Australasian journal of animal sciences · 2014Article
- Disruption of the murine Glp2r impairs Paneth cell function and increases susceptibility to small bowel enteritis.Endocrinology · 2012Article
- Synergistic effect of glucagon-like peptide 2 (GLP-2) and of key growth factors on the proliferation of cultured rat astrocytes. Evidence for reciprocal upregulation of the mRNAs for GLP-2 and IGF-I receptors.Molecular neurobiology · 2009Article
- Article
- Glucagon-like peptide-2 does not modify the growth or survival of murine or human intestinal tumor cells.Cancer research · 2008Article
- Evolution of the restorative proctocolectomy and its effects on gastrointestinal hormones.International journal of colorectal disease · 2007Review
- Gut hormones, and short bowel syndrome: the enigmatic role of glucagon-like peptide-2 in the regulation of intestinal adaptation.World journal of gastroenterology · 2006Review
- Intestinal adaptation after massive intestinal resection.Postgraduate medical journal · 2005Review
- Lactoferrin reduces methotrexate-induced small intestinal damage, possibly through inhibition of GLP-2-mediated epithelial cell proliferation.Digestive diseases and sciences · 2004Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Glucagon-like peptide 2 (GLP-2) is a potent intestine-specific growth factor. To determine whether GLP-2 has a direct effect on cellular proliferation, we examined the effects of GLP-2 on three different intestinal epithelial cell lines: Caco-2, T84, and IEC-6. Proliferation was assessed by measuring [3H]thymidine incorporation into cellular DNA. The expression of the cell cycle regulators cyclins D1, E, and A was determined by western blotting. GLP-2 stimulated [3H]thymidine incorporation in Caco-2 and T84 cells but not in IEC-6 cells. In Caco-2 cells, increased [3H]thymidine incorporation was detectable by day 1 and was maximal at day 5 following initiation of daily GLP-2 administration. Increased [3H]thymidine incorporation persisted for three days following treatment with a single dose of GLP-2. GLP-2 administration resulted in the induction of cyclins D1, E, and A in Caco-2 cells. These results suggest that GLP-2 acts directly on human intestinal epithelial cells to stimulate their proliferation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.